脑梗塞家族聚集性的病因和流行病学研究

本研究通过遗传流行病学病例对照方法，对宜兴市２１４个家系（１０９个脑梗塞先证家系和１０５个对照家系）进行了脑梗塞家族史的遗传易感性研究，结果表明：病例和对照家系有良好的均衡可比性，病例组一级亲属总的患病率为５．１２％，与对照组的１．６３％相比，差异有非常显著性，不论其父母或同胞，均以病例亲属的患病率显著高于对照，而子女中两者无显著性差异；二项分布显示，脑梗塞家族中实际发病数超过其二项分布的理论概率

A Study on The Etiology and Epidemiology of Familial Aggregation in Arteriosclerotic Cerebral Infarction

A ease-control study including 214 pedigrees (109 cases and 105 controls) was carried out to explore the etiology of family aggregation of arteriosclerotic cerebral infarction in Yi-Xing city, March 1997. The results showed that the family member in both cases and control groups were comparable. The total prevalence rate of the first-degree relatives in eases was 5.12%, significantly higher than (1.63%) that noticed in controls, with χ²=16.40 (P<0.01). The same results was also found in their parents and siblings. Results from hinominal distribution analysis showed that the number of cases in the families of arteriosclerotic cerebral infarction was signficantly higher than the therotical range which indicated that there was significant familial aggregation in the occurance of arteriosclerotic cerebral infarction. Logistic regression model also showed that genetic factor was one of the most important risk factors in Yi-xing, Jiangsu. Dose-response was observed in this model. The heritability and the segregation ratio of arteriosclerotic cerebral infarction were the same as seen in other chronic diseases, such as coronary heart disease and esophageal cancer.