膳食维生素C与代谢综合征风险的meta分析

目的用meta分析的方法定量评估膳食维生素C与代谢综合征(metabolic syndrome,MetS)风险的关系,为MetS的预防与治疗提供依据。方法系统检索PubMed、EMBASE、中国知网(CNKI)、万方数据库(WanfangData)以及维普数据库(VIP)中由建库至2021年12月公开发表的关于膳食维生素C与MetS风险关系的流行病学观察性研究。提取数据后,应用Stata 12.0软件进行meta统计分析。结果共纳入7篇文献,总样本量为29363人,包括8300例MetS患者。meta分析结果显示,膳食维生素C摄入量最高组发生MetS的风险较最低组低7%(RR=0.93,95%CI:0.89~0.98)。剂量-反应meta分析结果显示,膳食维生素C与MetS风险之间呈线性关系(非线性P>0.10),摄入量每增加50 mg/d并不能明显降低MetS的发生风险(RR=0.97,95%CI:0.92~1.02)。结论MetS与膳食维生素C摄入量之间存在关联性,高膳食维生素C摄入可降低MetS的风险。

Meta-analysis of dietary vitamin C and risk of metabolic syndrome

Objective To quantitatively evaluate the association between dietary vitamin C and metabolic syndrome (MetS) based on a meta-analysis, and to provide a basis for MetS prevention and treatment. Methods PubMed, EMBASE, CNKI, WanfangData and VIP databases were systematically searched for observational epidemiological studies on the association between dietary vitamin C and risk of MetS published from the establishment of the databases to December 2021. After the data extraction, a meta-analysis was performed with Stata 12.0. Results A total of 7 articles were enrolled in this analysis, involving 29,363 participants and 8,300 MetS patients. Meta-analysis results revealed that the group with the highest dietary vitamin C intake decreased the risk of MetS by 7% compared with the group with the lowest intake (RR=0.93, 95%CI:0.89-0.98). The dose-response meta-analysis showed a linear relationship between dietary vitamin C and the risk of MetS (non-linear P>0.10), with each 50 mg/d increase insignificantly reducing the risk of MetS (RR=0.97, 95%CI:0.92-1.02). Conclusion There is an association between MetS and dietary vitamin C intake amount, and high dietary vitamin C intake can reduce the risk of MetS.