中年人静息心率与心血管病发病风险的相关性研究

目的通过研究中年人群静息心率与心血管病危险因素及发病风险之间的关系,探讨静息心率在心血管病预测中的作用。方法调查2011年4月-2012年6月于本院体检的35~64岁无心血管疾病史的社区居民2 051名,通过问卷调查、体格检查、血清生化对其进行10年发病风险预测,分析静息心率与心血管病危险因素及10年发病风险之间的关系。结果 1)不论性别,血压值、空腹血糖值及糖尿病、高血压患病率在高心率组均明显高于低心率组。2)男性高心率组胆固醇水平、甘油三酯水平、吸烟、高血压家族史及2个以上危险因素者比例均明显高于低心率组(P均0.05),而女性差异无统计学意义(P0.05)。女性高心率组中心型肥胖比例明显升高(P=0.018),且心率与年龄呈负相关(P=0.005)。3)心率增快的独立危险因素的回归分析显示,男性包括吸烟、高血压家族史、高血压与糖尿病;女性包括年龄、腰臀比、高血压与糖尿病。4)男性心率与10年心血管病发病风险评分呈正相关(P=0.003),而女性差异无统计学意义(P=0.174)。结论在35~64岁男性人群,心率与10年心血管病发病风险呈正相关,上述人群监测静息心率对预测心血管疾病风险具有重要意义。

Correlation between the resting heart rate and the morbidity risk of cardiovascular disease in middle - aged people

Objective To study the relationships between the resting heart rate （RHR） and the affecting factors and risk of cardiovascular disease （CVD） incidence in middle - aged people, and to ass the value of RHR in prediction of CVD. Meth- ods We investigated 2,051 CVD - free community residents aged 35 - 64 years who visited the Forth Affiliated Hospital of China Medical University for health examination during April 2011 and June 2012. The morbidity risk of CVD in ten years among the residents were predicted through questionnaire survey, physical examination and biochemical detection. The relation- ships between RHR and the affecting factors and the morbidity risk of CVD were analyzed. Results In both genders, the levels of blood pressure and blood glucose and the incidence of hypertension and diabetes were all significantly higher in high- RHR group than in low- RHR group. The cholesterol and triglyceride levels and the proportions of the residents with smoking, family history of hypertension as well as with over two risk factors were all significantly higher in male high- RHR group than in male low- RHR group （all P〈 0.05）, while no statistically significant differences were found between female high- RHR group and female low- RHR group （P〉0.05）. The incidence of abdominal obesity in female high- Rt-IR group was significantly in- creased （P = 0. 018）, moreover, there was a negative correlation between RHR and age （P = 0. 005）. Regression analysis showed that the independent risk factors affecting RHR increment included smoking, family history of hypertension, hyperten- sion and diabetes in males and age, waist - to- hip ratio, hypertension and diabetes in females. RHR was positively correlated with the score of 10 - year CVD morbidity risk in males （P =0. 003）, but no statistically significant difference was found in fe- males （P = 0. 174）. Conclusions There is a positive correlation between RHR and 10 - year CVD morbidity risk in males aged 35 -64 years, and hence, RHR surveillanc