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| 海南汉族冠状动脉粥样硬化性心脏病人群CETP基因多态性与血脂的关系 | |
| 引用本文： | 张勇,习隽丽,云美玲,张云霞,周代锋,蔡望伟,王镇.海南汉族冠状动脉粥样硬化性心脏病人群CETP基因多态性与血脂的关系[J].现代预防医学,2011,38(4):691-693. |
| 作者姓名： | 张勇 习隽丽 云美玲 张云霞 周代锋 蔡望伟 王镇 |
| 作者单位： | 1. 海南省老年病医院,海口,571101 2. 海南医学院附属医院心内科 3. 海南医学院生物化学教研窒 4. 海南医学院生物化学教研室 |
| 基金项目： | 海南省自然科学基金立项课题，海南医学院苗圃基金资助课题 |
| 摘 要： | 目的]了解CETP基因TaqIB、I405V、D442G、R451Q、A373P和I14A6种突变的多态性与海南汉族CHD人群血脂的关系。方法]应用等位基因特异性PCR技术,对301例海南汉族正常对照组、334例海南汉族CHD患者组中CETP基因多态位点进行检测,分析各基因型与血脂的关系。结果]在2组人群中,TaqIB、I405V和D442G多态位点可分别检测出B1B1、B1B2、B2B23种基因型,II、IV、VV3种基因型和DD、DG2种基因型,未检测到R451Q、A373P和I14A3种突变类型。I405V和D442G2个多态位点的基因型分布和等位基因频率在2组间存在统计学差异,且与CHD组中总胆固醇浓度升高有关;D442G多态位点的基因型分布和等位基因频率还与CHD组中高密度脂蛋白浓度升高有关。其余多态位点在2组间及与CHD血脂水平之间无差异。结论]I405V和D442G的多态性与海南汉族CHD显著相关,且与CHD总胆固醇升高相关;D442G的多态性还与海南汉族CHD的HDL升高相关。 |
| 关 键 词： | 胆固醇酯转运蛋白基因 DNA多态性 冠状动脉粥样硬化性心脏病 汉族 |
STUDY ON THE RELATIONSHIP BETWEEN CETP POLYMORPHISM AND PLASMA LIPID IN PATIENT WITH CHD OF HAN ETHNIC IN HAINAN |
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| ZHANG Yong,XI Jun-li,YUN Mei-ling,et al..STUDY ON THE RELATIONSHIP BETWEEN CETP POLYMORPHISM AND PLASMA LIPID IN PATIENT WITH CHD OF HAN ETHNIC IN HAINAN[J].Modern Preventive Medicine,2011,38(4):691-693. | |
| Authors: | ZHANG Yong XI Jun-li YUN Mei-ling |
| Affiliation: | ZHANG Yong,XI Jun-li,YUN Mei-ling,et al.(Gerontology Hospital,Haikou 571101,China) |
| Abstract: | Objective] To understand the correlations between the polymorphism of CETP gene at six mutation loci,TaqIB,I405V,D442G,R451Q,A373 and I14A,and coronary heart disease(CHD) of Han ethnic in Hainan province.Methods] The six polymorphic loci of CETP gene was probed with an allele specific-PCR(AS-PCR) in 301 healthy controls and 334 CHD patients of Han ethnic in Hainan province.The diverse genotypes and their association with blood fat levels were studied.Results] In both the healthy controls and the CHD pati... |
| Keywords: | Cholesterol ester transfer protein(CETP) gene DNA polymorphism Coronary atherosclerotic heart disease(CHD) Han nationality |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
