| 叶酸和维生素B12对糖尿病患者同型半胱氨酸和氧化应激水平的影响 |
| |
| 引用本文： | 郭沛艳,宋淑萍,罗惠辛,窦若兰,王娟,张向英,胡若梅,王湛,魏慧芸.叶酸和维生素B12对糖尿病患者同型半胱氨酸和氧化应激水平的影响[J].现代预防医学,2011,38(16):3184-3186. |
| |
| 作者姓名： | 郭沛艳 宋淑萍 罗惠辛 窦若兰 王娟 张向英 胡若梅 王湛 魏慧芸 |
| |
| 作者单位： | 天津市天和医院,天津,300050 |
| |
| 摘 要： | 目的]探讨叶酸和维生素B12在防治糖尿病的作用及其作用机理。方法]采用病例对照实验研究方法,观察糖尿病患者叶酸联合维生素B12治疗后血清同型半胱氨酸水平、氧化应激相关指标等的影响。结果]该治疗可降低糖尿病患者血清同型半胱氨酸、丙二醛(MDA)水平,并可升高一氧化氮(NO)、超氧化物歧化酶(SOD)水平。结论]叶酸联合维生素B12干预后,糖尿病患者同型半胱氨酸水平降低,氧化应激状态改善,因此补充叶酸和维生素B12可成为一种早期防治糖尿病的新的、有效的和经济的方法。
|
| 关 键 词： | 叶酸 维生素B12 氧化应激 糖尿病 |
THE EFFECT OF FOLIC ACID AND VITAMIN B12 ON THE LEVELS OF THE HOMOCYSTEINE AND THE OXIDATIVE STRESS IN PATIENTS WITH DIABETES |
| |
| GUO Pei-yan,SONG Shu-ping,LUO Hui-xin,et al..THE EFFECT OF FOLIC ACID AND VITAMIN B12 ON THE LEVELS OF THE HOMOCYSTEINE AND THE OXIDATIVE STRESS IN PATIENTS WITH DIABETES[J].Modern Preventive Medicine,2011,38(16):3184-3186. |
| |
| Authors: | GUO Pei-yan SONG Shu-ping LUO Hui-xin |
| |
| Affiliation: | GUO Pei-yan,SONG Shu-ping,LUO Hui-xin,et al.(Tianjin Tianhe Hospital,Tianjin 300050,China) |
| |
| Abstract: | Objective]To investigate the use of folic acid and vitamin B12 in the prevention and treatment of diabetes and its mechanism.Methods]Through case-control study,we observed the change of the serum homo-cysteine levels and oxidative stress-related indicators after treatment using folic acid combined with vitamin B12 in patients with diabetes.Results]This treatment for diabetic patients could reduce serum homocysteine and malondialdehyde(MDA)levels,and increase nitric oxide(NO),superoxide dismutase(SOD)leve... |
| |
| Keywords: | Folic acid Vitamin B12 Oxidative stress Diabetes |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
