淋巴毒素α基因rs1800683 G>A位点多态性与川崎病的关联性研究

目的 通过检测淋巴毒素α(LTA)基因rs1800683 G>A位点多态性,探讨淋巴毒素α基因rs1800683 G>A位点多态性与川崎病(KD)发病及KD冠脉损伤的关联性。方法 应用基因测序方法,对100例KD组与92例健康对照组儿童淋巴毒素α基因rs1800683 G>A位点多态性进行基因检测;结果 KD组的淋巴毒素α基因rs1800683 G>A位点AG、AA、GG基因型分布和A、G等位基因频率与健康对照组比较差异无统计学意义(χ²=3.78和2.84,P均>0.05),KD组的合并CAL组与NCAL组基因型和等位基因频率比较差异亦无统计学意义(χ²=3.76和0.43,P均>0.05)。结论 未发现淋巴毒素α基因rs1800683 G>A位点多态性与KD的发病及其冠脉损伤存在明显关联性。

Association of locus rs1800683 G>A polymorphisms of lymphotoxin-alpha gene with Kawasaki disease.

Objective To investigate the relationship between the locus rs1800683 G>A polymorphisms of lymphotoxin-alpha (LTA) gene with Kawasaki disease (KD). Method The Sanger gene sequencing method was employed to detect the genotype of locus rs1800683 G>A polymorphisms of LTA gene in 100 patients with KD and 92 healthy controls. Results For locus rs1800683 G>A polymorphism in LTA gene,there was no significant difference between the KD and healthy controls in genotyping frequencies of AG,AA and GG respectively (χ²=3.78,P>0.05),and there was no significant difference in the allele frequencies of A and G between the two groups (χ²=2.84,P>0.05).There were no significant differences between the KD complicated with coronary artery injury (CAL) group and non coronary artery lesion (NCAL) group in genotyping frequencies of AG,AA and GG respectively (χ²=3.76,P>0.05) and in the allele frequencies of A and G between the two groups (χ²=0.43,P>0.05). Conclusion The locus rs1800683 G>A polymorphisms of LTA gene maybe not associated with the risks of KD and the coronary artery injury.