| 产前免疫治疗后孕妇血清HBV DNA水平与HBV母婴传播的关系 |
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| 引用本文： | 汤佩玲,胡淑君.产前免疫治疗后孕妇血清HBV DNA水平与HBV母婴传播的关系[J].中国感染控制杂志,2004,3(3):202-204. |
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| 作者姓名： | 汤佩玲 胡淑君 |
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| 作者单位： | 广州医学院第一附属医院,广东,广州,510120 |
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| 摘 要： | 目的探讨乙型肝炎表面抗原(HBsAg)阳性孕妇产前免疫治疗后血清中乙型肝炎病毒(HBV)DNA水平与母婴传播的关系。方法对87例HBsAg阳性孕妇于妊娠晚期应用乙型肝炎免疫球蛋白后，采用荧光定量PCR法检测其分娩前静脉血、脐血及乳汁的HBV DNA。结果随孕妇血清HBV DNA含量的升高，胎儿发生宫内感染和初乳排毒的危险性呈增高趋势。结论孕妇血清HBV DNA含量与是否发生母婴传播密切相关。
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| 关 键 词： | 肝炎病毒，乙型 母婴传播 HBV DNA 乳人 |
| 文章编号： | 1671-9638(2004)03-0202-03 |
| 修稿时间： | 2003年12月15 |
The relationship of the level of hepatitis B virus DNA in maternal blood after immunotherapy and maternal-fetal transmission of HBV |
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| TANG Pei ling,HU Shu jun.The relationship of the level of hepatitis B virus DNA in maternal blood after immunotherapy and maternal-fetal transmission of HBV[J].Chinese Journal of Infection Control,2004,3(3):202-204. |
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| Authors: | TANG Pei ling HU Shu jun |
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| Abstract: | Objective To study the relationship of the level of hepatitis B virus DNA in maternal blood after immunotherapy and the maternal fetal transmission. Methods Eighty seven pregnant women with positive HBsAg were injected with hepatitis B immunoglobulin during the third trimester of pregnancy, HBV DNA from venous blood, umbilical blood and breast milk was detected by fluorescence quantitative polymerase chain reaction (FQ PCR). Results With the increase of maternal serum HBV DNA, the risk of fetal intrauterine infection and secretion of virus in colostrum was increased. Conclusion The increase of maternal HBV DNA level is closely related to the occurrence of important factors for intrauterine infection. |
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| Keywords: | hepatitis B virus maternal fetal transmission HBV DNA milk human |
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