特殊涉核环境人员黄斑区厚度研究

目的 探讨特殊涉核环境人员与普通环境非涉核人员黄斑区厚度的差异性。方法 在某基地年度体检时为特殊涉核环境人员（简称涉核人员）与普通环境非涉核人员（简称非涉核人员）增加眼科光学相干断层扫描（Optical coherence tomography，OCT）检查，测量黄斑区厚度值，每人测量3次，按照体检表末尾编号随机抽取204例编号为奇数的涉核人员和105例非涉核人员，取3次测量值的平均值进行比较。结果 涉核人员与非涉核人员两组年龄均值为（29.40 ±6.16）岁、（28.92 ±6.71）岁，P = 0.5325，无统计学差异。两组人员视力均值：涉核人员为（1.04 ±0.03）（右），（1.05 ±0.03）（左），非涉核人员为（1.00 ±0.05）（右），（1.02 ±0.05）（左），P = 0.5006（右），P = 0.5962（左），无统计学差异。涉核人员黄斑区厚度均值：（212.9 ±1.3） μm（右），（205.5 ±1.1） μm（左），P < 0.0001，两者比较差异有统计学意义；非涉核人员黄斑区厚度均值：（223.2 ±2.5） μm（右），（211.7 ±2.4） μm（左），P < 0.0001，两者比较有统计学差异。对涉核人员与非涉核人员右眼及左眼黄斑区厚度均值进行比较，P = 0.0003（右），P = 0.0217（左），均有统计学差异。结论 非涉核人员黄斑区厚度要厚于涉核人员。与涉核人员特殊工作环境中较多使用LED光源可能存在关联；其他因素包括涉核、气压、氧分压及人员的心理状态需要进一步的试验进行证明。

Research on the thickness of fovea in macular area in nuclear personnel

Objective To investigate the difference of thickness of macular area between personnel with special nuclear involvement and those without nuclear involvement.Method During the annual physical examination, the Optical coherence tomography (OCT) examination was added to measure the thickness of the macular area for personnel with special nuclear involvement and those without nuclear involvement in the general environment. Each person should take three times of measurements, and 204 nuclear personnel with odd numbers and 105 non-nuclear personnel were randomly selected according to the number at the end of the physical examination form. We took the average of the 3 times of measurements for comparison.Results The mean age of nuclear-related personnel and non-nuclear-related personnel was aged (29.40 ±6.16) and (28.92 ±6.71), respectively. The difference was not statistically significant, P = 0.5325. Mean visual acuity of the two groups: nuclear-related personnel was (1.04 ±0.03)(R), (1.05 ±0.03)(L), non-nuclear-related personnel was (1.00 ±0.05)(R), (1.02 ±0.05)(L), P = 0.5006(R), P = 0.5962(L). There was no significant difference in visual acuity between the two groups. Mean thickness in the macular area of nuclear-related personnel: (212.9 ±1.3) μm(R), (205.5 ±1.1) μm(L), P < 0.0001, the difference was statistically significant. Mean thickness in the macular area of non-nuclear-related personnel: (223.2 ±2.5) μm(R), (211.7 ±2.4) μm(L), P < 0.0001, the difference was also statistically significant. The differences of mean thickness of macular area of nuclear-related personnel and non-nuclear-related personnel were statistically significant, P = 0.0003(R), P = 0.0217(L).Conclusion The thickness of the macular area of non-nuclear-related personnel is thicker than that of nuclear-related personnel. It may be related to the excessive use of LED light sources in the special working environment of nuclear-related personnel. Other factors include nuclear, air pressure, oxygen partial pressure and the psychological state of the human being, which need to be proved by more detailed experiments.