大肠管状腺癌磁共振扩散加权成像ADC值与肿瘤分化程度的相关性

目的 探讨磁共振扩散加权成像（DWI）及表观扩散系数（ADC）值与结直肠管状腺癌分化程度的相关性。方法 回顾性分析经病理证实为结直肠管状腺癌36例病例资料，术前行MRI、DWI及增强检查且均未行新辅助化疗或放疗，分别测量病灶ADC值，采用Pearson相关分析统计ADC值与分化程度的相关性。结果 低分化组2例，平均ADC值为（0.734±0.070）×10^-3mm²/s；中分化组24例，平均ADC值为（0.966±0.157）×10^-3 mm²/s；高分化组10例，平均ADC值为（1.244±0.156）×10^-3mm²/s。ADC值与结直肠管状腺癌分化程度呈强相关（r=0.692，P=0.000），高中低分化的三组间ADC值对照无统计学意义，低-中分化组与高分化组进行对照（P=0.000），结果差异有统计学意义。结论 不同分化程度的结直肠管状癌的ADC值均随着肿瘤的分化程度降低而减低，两者具有相关性，为术前评价结直肠管状腺癌分化程度提供有力依据，ADC值测量在一定程度上可快捷地预判肿瘤的恶性程度。

Correlation between ADC value of MR diffusion-weighted imaging and grading in colorectal adenocarcinoma

Objective To investigate the correlation between apparent diffusion coefficient (ADC)value of MR diffusion weighted imaging (DWI)and grading in colorectal adenocarcinoma.Methods The data of 36 patients with colorectal neoplasms confirmed by pathology were retrospectively analyzed. MRI、DWI and enhanced examination were performed preoperatively. ADC values were calculated in each group to analyze the correlation with the grading colorectal adenocarcinoma by pearson correlation analysis.Results The mean ADC value were(0.734±0.070)×10^-3 mm²/s in the poorly differentiated group(2 cases), (0.966±0.157)×10^-3 mm²/s in the moderately differentiated group (10 cases).ADC value and grading colorectal adenocarcinoma were strong correlated (r=0.692,P=0.000). The three groups of high and low score ADC values were not statistically significant, The difference between the moderately differentiated group and the well-differentiated group (P=0.000) was statistically significant.Conclusion The ADC values of colorectal tubular carcinomas with different degrees of differentiation decrease with the degree of differentiation of the tumors. The two are correlated and provide a strong basis for evaluating the differentiation of colorectal tubular adenocarcinoma preoperatively. DWI and ADC measurement can evaluate the grade of malignancy and prognosis of colorectal tumor to some extent.