罗伊氏乳杆菌对轮状病毒感染肠炎患儿免疫功能与肠道菌群及临床疗效的影响

目的探究罗伊氏乳杆菌DSM 17938在治疗轮状病毒感染肠炎患儿中的疗效及对免疫功能、肠道菌群的影响。方法收集于2018年2月-2019年2月在阳光融和医院进行诊治的轮状病毒感染肠炎患儿126例,随机分为试验组(63例)和对照组(63例)。对照组给予常规补液治疗及蒙脱石散和枯草杆菌二联活菌口服治疗,试验组采用常规补液治疗及蒙脱石散和罗伊氏乳杆菌DSM 17938辅助治疗。观察两组患儿的腹泻改善情况,并分析对免疫功能(IgG、IgA、CD4^+/CD8^+水平)及肠道菌群失调的影响。结果在治疗72 h后,试验组患儿的治疗总有效率为92.06%,高于对照组的74.60%(P=0.009);且治疗后两组患儿的IgG、IgA、CD4^+/CD8^+水平均较治疗前有升高(P<0.05),且试验组水平高于对照组(P<0.05)。对患儿肠道菌群进行分析,在治疗1周后,试验组患儿肠道菌群失调程度低于对照组,且试验组的肠道菌群正常比例高于对照组(P<0.05)。结论罗伊氏乳杆菌DSM 17938对于辅助治疗轮状病毒感染肠炎患儿具有良好的疗效,能够提高患儿免疫力,改善肠道菌群失调,减轻患儿腹泻症状,具有一定的临床应用价值。

Effect of Lactobacillus reuteri on immune function and intestinal flora and its clinical function in children with rotavirus-infected enteritis

OBJECTIVE To investigate the efficacy of Lactobacillus reuteri DSM 17938 in the treatment of children with rotavirus-induced enteritis and its effects on immune function and intestinal flora.METHODS A total of 126 children with rotavirus-infected enteritis who were treated in our hospital from February 2018 to February 2019 were randomly divided into the observation group(63 cases)and the control group(63 cases).The control group received conventional rehydration therapy and oral administration of montmorillonite powder and bacillus subtilis.The observation group was given rehydration therapy and oral administration of montmorillonite powder and L.reuteri DSM 17938.The improvement of diarrhea in the two groups was observed,and indexes of immune function(IgG,IgA,CD4^+/CD8^+levels)and the effect on the intestinal flora balance were analyzed.RESULTS After 72 hours of treatment,the total effective rate in the treatment group was 92.06%,which was significantly higher than that in the control group(74.60%)(P=0.009).After the treatment,the IgG,IgA,CD4^+/CD8^+levels in both groups increased significantly than that before the treatment(P<0.05),and levels of indexes in the observation group was significantly higher than that in the control group(P<0.05).The intestinal flora in the children was analyzed.After 1 week of treatment,the degree of intestinal flora imbalance in the observation group was significantly lower than that in the control group,and the normal proportion of intestinal flora in the observation group was significantly higher than that in the control group(P<0.05).CONCLUSION L.reuteri DSM 17938 had a good curative effect on the children with rotavirus infection enteritis.It can improve the immunity of children,improve the intestinal flora balance,and alleviate the symptoms of diarrhea in children,which may have certain clinical application value.