| 衰老大鼠性激素与其受体的变化以及何首乌饮对其影响的研究 |
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| 引用本文： | 李亚丽,张娜,郭文潮,余小平,楚伟.衰老大鼠性激素与其受体的变化以及何首乌饮对其影响的研究[J].中国妇幼保健,2011,26(1):106-109. |
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| 作者姓名： | 李亚丽 张娜 郭文潮 余小平 楚伟 |
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| 作者单位： | 1. 河北省人民医院优生优育优教中心,河北,石家庄,050071
2. 河北医科大学第四医院生殖中心 |
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| 摘 要： | 目的:探讨衰老雌性大鼠性激素及其受体的变化情况和何首乌饮延缓卵巢组织衰老的作用机制。方法:D-半乳糖连续腹腔注射致亚急性衰老动物模型,造模后灌胃何首乌饮连续60天后,大鼠断头取垂体、卵巢。采用全自动微粒子化学发光免疫分析方法检测各组大鼠血清LH,E2,FSH的含量;原位杂交方法检测各组大鼠卵巢细胞FSHR和LHR的变化;West-ern Bloting法检测各组大鼠卵巢ER的变化。结果:同正常对照组相比,模型组大鼠垂体指数和卵巢指数均明显降低,血清E2含量明显降低,LH、FSH升高,ER、FSHR、LHR的表达明显降低,差异有统计学意义(P<0.05)。与模型组比较,何首乌饮组垂体指数和卵巢指数均明显增高,血清E2含量明显升高,LH、FSH降低,ER、FSHR、LHR的表达明显升高,呈现一定的剂量依赖性。结论:衰老时大鼠卵巢正常功能被破坏,何首乌饮通过对性激素和其受体的调节而延缓卵巢的衰老。
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| 关 键 词： | 何首乌饮 卵巢 性激素 |
Investigation on changes of sex hormones and their receptors and the effect of polygonum multiflorum drink on aging rats |
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| LI Ya-Li,ZHANG Na,GUO Wen-Chao et al.People's Hospital of Hebei,Shijiazhuang ,Hebei,China.Investigation on changes of sex hormones and their receptors and the effect of polygonum multiflorum drink on aging rats[J].Maternal and Child Health Care of China,2011,26(1):106-109. |
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| Authors: | LI Ya-Li ZHANG Na GUO Wen-Chao People's Hospital of Hebei Shijiazhuang Hebei China |
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| Affiliation: | LI Ya-Li,ZHANG Na,GUO Wen-Chao et al.People's Hospital of Hebei,Shijiazhuang 050071,Hebei,China |
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| Abstract: | Objective:To explore the changes of sex hormones and their receptors and the mechanism of polygonum multiflorum drink in delaying aging of ovarian tissues in rats.Methods:The rat models of acute aging were established by continuous intraperitoneal injection of D-galactose,after intragastric administration of polygonum multiflorum drink for 60 days,the rats were executed by decollation,their pituitary and ovary were obtained;automatic microparticle chemiluminescence immunoassay was used to detect the content... |
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| Keywords: | Polygonum multiflorum drink Ovary Sex hormones |
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