子宫内膜异位症及卵巢癌腹腔IL-6、IL-8变化的临床意义

目的:探讨白细胞介素6(IL-6)、白细胞介素8(IL-8)与子宫内膜异位症(endomotriosisEMs)卵巢癌的发生发展关系。方法:采用双抗体夹心ABC-酶联免疫吸附实验(ELISA)对EMs患者30例、血清及腹腔液中IL-6、IL-8进行检测,并以卵巢癌患者10例、卵巢良性肿瘤患者30例、正常妇女血清30例做对照组。结果:EMs组与卵巢癌组患者血清及腹腔液中IL-6、IL-8水平明显高于对照组(P<0.01),EMs组与卵巢癌组对比无显著性差异(P>0.05)。结论:EMs患者腹腔液中IL-6、IL-8异常增高是腹腔免疫内环境失衡,与EMs的发生发展有关,在药物治疗中血清IL-6、IL-8可作为EMs疗效和预后的指标之一。

The role of IL -6 , IL -8 in pathogenesis of endometriosis and ovarian cancer

Objective:To study the relationship IL-6 IL8 with occurrence and development of endometriosis and ovarian cancer.Methods:Thirty patients with endometriosis and as were selected as study group.Ten of patients with ovarian cancer.Thirty patients with benige ovarian tumor and thirty normal women as control group.IL-6,IL-8 concentrations in peritoneal fluid and serum were detected by enzyme linked immunoabsorbent assay(ELISA).Results:The serum and peritoneal fluid levels of IL-6,IL-8 were significantly higher in the endometriosis and ovarian cancer than those in the controls(P<0.01),but were not significantly between endometriosis and ovarian cancer(P>0.05).Conclusion:Unusual levels of IL-6 IL-8 in peritoneal fluid of endometriosis patients account for imbalance of immunological.It may play a role in pathogenesis of endometriosis.Detection of serum IL-6 and IL-8 levels in patients with endometriosis might be one of assessing the curative effect and prognosis.