单唾液酸四己糖神经节苷脂钠注射液对新生儿缺氧缺血性脑病神经行为的影响

目的:观察单唾液酸四己糖神经节苷脂钠注射液对新生儿缺氧缺血性脑病(HIE)神经行为的影响及其临床疗效。方法:收集该院2009年10月～2011年10月2年间治疗的HIE患儿54例,HIE患儿随机分为常规治疗(A)组和单唾液酸四己糖神经节苷脂钠注射液治疗(B)组。对照两组的意识障碍、肌张力异常、原始反射异常的持续时间以及新生儿神经行为(NBNA)评分。统计分析两组的临床疗效。结果:意识障碍、肌张力异常、原始反射异常的持续时间A组显著长于B组(P<0.05),新生儿神经行为(NBNA)B组则显著高于A组(P<0.05)。A组显效7例,有效12例,无效8例,有效率为70.4%;B组显效14例,有效11例,无效2例,有效率为92.6%,统计学分析显示临床治疗有效率B组显著高于A组(P<0.05)。结论:单唾液酸四己糖神经节苷脂钠注射液治疗HIE患儿可以显著改善其神经行为的异常,临床疗效显著,值得临床推广应用。

Effect of monosialoteterahexosyl ganglioside sodium injection on neurobehavior of neonates with hypoxic-ischemic encephalopathy

Objective:To observe the effect of monosialoteterahexosyl ganglioside sodium injection on neurobehavior of neonates with hypoxic-ischemic encephalopathy(HIE) and the clinical efficacy.Methods:Fifty-four neonates with HIE who were treated in the hospital from October 2009 to October 2011 were collected and divided into group A(routine therapy) and group B(monosialoteterahexosyl ganglioside sodium injection).The duration times of conscious disturbance,dystonia and primary reflex abnormality,and NBNA score in the two groups were compared.The clinical efficacies in the two groups were analyzed statistically.Results:The duration times of conscious disturbance,dystonia,and primary reflex abnormality in group A were statistically significantly longer than those in group B(P<0.05).NBNA score in group B was statistically significantly higher than that in group A(P<0.05).The therapy was obviously effective in seven neonates,effective in twelve neonates,and ineffective in eight neonates in group A,the effective rate was 70.4%;while the therapy was obviously effective in fourteen neonates,effective in eleven neonates,and ineffective in two neonates in group B,the effective rate was 92.6%.The effective rate of clinical treatment in group B was statistically significantly higher than that in group A(P<0.05).Conclusion:Monosialoteterahexosyl ganglioside sodium injection can significantly improve abnormalities of neurobehavior for treatment of neonates with HIE,the clinical efficacy is dominant,and the method is worthy to be popularized and applied in clinic.