| EB病毒与乳腺癌的相关性研究进展 |
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| 引用本文： | 何健荣,宋尔卫,任泽舫.EB病毒与乳腺癌的相关性研究进展[J].癌症,2009,28(8):827-830. |
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| 作者姓名： | 何健荣 宋尔卫 任泽舫 |
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| 作者单位： | 何健荣,任泽舫(中山大学公共卫生学院医学统计与流行病学系,广东广州,510080);宋尔卫(中山大学附属第二医院乳腺肿瘤中心,广东,广州510120) |
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| 摘 要： | 乳腺癌的病因尚未明确，已知的危险因素包括生殖因素、影响体内性激素水平因素和遗传易感因素，但这些因素也只能解释约50%腺癌病例。近年来有研究试图从病毒感染的角度探讨乳腺癌的病因，EB病毒（Epstein—Barrvirus，EBV）正是研究热点之一。但EBV与乳腺癌的关系仍存在着很大的争议。本文就EBV生物学特点、EBV与乳腺癌的相关性研究（包括癌组织中的EBV检测、血清学研究、细胞学实验和临床特点分析）作一综述，并提出目前存在的问题和今后研究的方向。
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| 关 键 词： | EB病毒 乳腺肿瘤 相关性 |
Research advancement on relationship between Epstein-Barr virus and breast cancer |
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| Affiliation: | Jian-Rong He, Er-Wei Song and Ze-Fang Ren(1. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R. China 2. Breast Tumor Center, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, P.R. China) |
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| Abstract: | The etiology of breast cancer factors, including reproductive and other s still unclear. The factors affecting well-known risk circulating sex hormones, and genetic susceptibility, explain only about 50% of all breast cancer incidence. More and more studies have shown interest in the possibility that breast cancer may be caused by viral infection. Epstein-Barr virus （EBV） is one of the candidate viruses, but the association of EBV with breast cancer remains controversial. Here we reviewed the studies on EBV biology and the association of EBV with breast cancer, including EBV detection in breast cancer tissues, serological tests, cytologic experiments and clinical analyses, and described the limitations of current studies and future directions |
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| Keywords: | Epstein-Barr virus breast neoplasm association |
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