早期乳腺癌延长内分泌治疗的研究进展

乳腺癌是常见的女性恶性肿瘤.大多数激素受体阳性乳腺癌能够早期诊断并使用辅助内分泌治疗,但乳腺癌复发的风险在5年辅助内分泌治疗后持续存在,且具有累积性.为了减轻这些风险,既往研究已经评估了延长内分泌治疗的使用.文章选择内分泌治疗方案和延长内分泌治疗的相关数据,总结延长内分泌治疗的意义及可能从中受益的患者、当前内分泌治疗可...

Progress of Extended Adjuvant Endocrine Therapy for Early-Stage Breast Cancer

Breast cancer is the most commonly diagnosed cancer in the world. While most hormone receptor-positive breast cancers can be diagnosed at an early stage and treated with adjuvant endocrine therapy, the risk of breast cancer recurrence persists and accumulates despite current therapeutic approaches. In attempt to mitigate these risks, previous clinical trials have evaluated the practice of extended endocrine therapy. This article provides an overview of the effectiveness of extended endocrine therapy and the possible side effects of current endocrine therapy. In general, overall survival benefit has been demonstrated with extended tamoxifen treatment, whereas the use of extended aromatase inhibitors has shown modest disease-free survival benefit. Therapeutic approaches for individual patients should depend on the possible benefit and tolerability of extended endocrine therapy.