339例中晚期胸段食管鳞癌术后生存评价及预后因素分析

目的探讨影响中晚期胸段食管鳞癌患者术后生存和预后的因素。方法采用COX比例风险模型回顾性分析新疆肿瘤医院行胸段食管癌根治术339例病例的临床资料。结果中晚期胸段食管鳞癌患者总1、3、5年生存率分别为80.49%、41.94%、23.12%,单因素分析显示体重减轻、血红蛋白水平、术前白蛋白水平、淋巴结转移个数、侵润深度、术后病理分期、脉管瘤栓与生存时间有关（P〈0.05）;多因素分析显示肿瘤侵润深度、淋巴结转移个数、术后病理分期、术前白蛋白水平是影响中晚期胸段食管鳞癌预后的独立因素。结论肿瘤侵润深度、淋巴结转移个数、术后病理分期、术前白蛋白水平是影响中晚期胸段食管鳞癌患者术后生存的独立因素。

Survival evaluation and prognostic factor of 339 patients with middle and late stage squamous cell carcinoma of thoracic esophagus after curative esophagectomy

Objective To evaluate the survival status and prognosis factors of the middle and late stage squamous cell carcinoma of the thoracic esophagus.Methods The clinicopathologic data of 339 patients with middle and late stage squamous cell carcinoma of the thoracic esophagus,treated with surgery from Jan 2002 to Dec 2006 in Xinjiang Tumor Hospital,were analyzed by COX regression model.Results The 1-,3-and 5-yeaa overall survival rates were 80.49%,41.94% and 23.12%,respectively.Univariate analysis revealed that the factors affecting the prognosis included weight loss,hemoglobin level,albumin level,depth of invasion,number of lymph node metastatic,tumor embolus existence in the lymph vessel and pathologic stage.Multivariate analysis showed that depth of invasion,number of lymph node metastatic,pathologic stage and albumin level were independent prognostic factors.Conclusion The independent prognostic factors of middle and late stage squamous cell carcinoma of the thoracic esophagus are depth of invasion,number of lymph node metastatic,pathologic stage and albumin level.