可手术切除食管癌综合治疗进展

最近几年食管癌治疗方式可选择性逐渐增加,手术仍是早期食管癌主要治疗手段,术前新辅助治疗、术后辅助治疗已逐渐成为可手术食管癌综合治疗的重要组成部分.根治性同期化放疔有可能代替单纯手术作为可手术食管癌治疗的选择.顺铂联合氟尿嘧啶仍是可手术食管癌手术前后辅助治疗的基本方案;新的细胞毒药物如紫杉醇类、拓扑异构酶抑制剂及新联合方案是围手术期治疗研究的热点.

Progress in multidisciplinary treatment of resectable esophageal cancer

In recent years, there has been a gradual increase in treatment options for patients with esophageal cancer. While surgery remains to be the primary treatment, neoadjuvant and adjuvant therapy, both preoperatively and postoperatively, have become more important in the multidisciplinary treatment of resectable esophageal cancer. Definitive concomitant chemo-radiotherapy may replace surgery as the primary treatment for resectable esophageal cancer. Cisplatin combined with 5-fluorouracil remains the backbone regimen for neoadjuvant and adjuvant therapy. Intense researches are underway to investigate new cytotoxic drugs such as taxanes and topoisomerase inhibitor, and new regimens for perioperative treatment of resectable esophageal cancer.