超声分子成像技术定量评估肿瘤微血管生成的研究进展

 靶向超声造影剂微泡构建的方法主要有两种方式。靶向新生血管的超声微泡造影剂主要分为连接抗αVβ3抗体、连接αVβ3整合素抗体及连接血管内皮生长因子受体2(VEGFR2)等几种。目前通过靶向微泡黏附于肿瘤靶标的定量分析以及评估黏附于肿瘤新生血管内皮细胞上的靶向微泡与肿瘤局部病理微血管密度之间的相关性认为超声分子成像可以无创、快捷、反复、动态，定量评估肿瘤的微血管生成情况，间接反映恶性肿瘤组织增殖活性及其生物学特性

Quantitative evaluation of tumor angiogenesis using ultrasound molecular imaging

This paper summarizes the new progress of the research of the targeted microbubble ultrasound contrast agents and ultrasound molecular imaging in tumor angiogenesis. There are two constructing methods of targeted microbubble ultrasound contrast agents. Targeted new blood vessels microbubble unltrasound contrast agents are mainly divided into the connection of alpha (V) beta3 antibody, αVβ3 integration antibody and connecting VEGFR2. The quantitative analysis of targeted microbubble adhering to tumor target and the evaluation of the correlation between targeted microbubble adhering to tumor neovascular endothelial cell and tumor local pathological microvessel density suggest that ultrasound molecular imaging can be noninvasive, quick, repeated, dynamic and quantitative evaluate tumor angiogenesis and indirectly reflect the malignant tumor tissue proliferation activity and its biological characteristics.