乙肝相关性肝癌临床病理学特征与高敏C反应蛋白和溶血磷脂酸表达的相关性

目的探讨乙肝相关性肝癌临床病理学特征与溶血磷脂酸(LPA)和高敏C反应蛋白(hs-CRP)表达的相关性。方法选取2019年1月至2020年1月间河南省驻马店市中心医院收治的198例乙肝相关性肝癌患者作为乙肝组,198例酒精相关性肝癌患者作为酒精组。两组患者都进行血清hs-CRP和LPA表达检测,调查患者的病理学特征并进行相关性分析。结果乙肝组患者血清hs-CRP和LPA含量均高于酒精组,差异均有统计学意义(均P <0.05)。两组患者血清ALP、AFP、ALT、AST和GGT含量比较,差异均无统计学意义(P> 0.05)。乙肝组不同临床分期和组织学分化患者的血清hs-CRP和LPA含量比较,差异均有统计学意义(均P <0.05)。乙肝组患者的临床分期和组织学分化与血清hs-CRP和LPA表达均存在相关性,差异均有统计学意义(均P <0.05)。患者的临床分期和组织学分化均为影响hs-CRP和LPA表达的重要因素,差异均有统计学意义(均P <0.05)。结论相对于酒精相关性肝癌,乙肝相关性肝癌的血清hs-CRP和LPA呈现高表达,与患者的临床病理学特征存在相关性。

Correlation between clinicopathological features and expression of hs-CRP and Lpa in hepatitis B related liver cancer

Objective To investigate the correlation between the clinicopathological features of hepatitis B related liver cancer and the expression of high sensitivity C-reactive protein(hs-CRP) and lysophosphatidic acid(LPA). Methods From January 2019 to January 2020,a total of 198 patients with hepatitis B related liver cancer were selected and included in a hepatitis B group and the another 198 patients with alcohol associated liver cancer patients were selected and included in a alcohol group at Zhumadian Central Hospital.All patients received serum hs-CRP and LPA expression tested. The pathological characteristics were investigated and analyzed. Results The serum levels of hs-CRP and LPA were higher in the hepatitis B group than those in the alcohol group(all P < 0. 05). There was no significant difference in the levels of alkaline phosphatase(ALP),alpha fetoprotein(AFP),alanine aminotransferase(ALT),glutamic pyruvic transaminase(ALT) and glutamyl aminotransferase(GGT) between the two groups(P >0. 05). In the hepatitis B group,there were significant difference in serum hs-CRP and LPA among patients of different histological differentiation and clinical stages(all P < 0. 05). Clinical stage and histological differentiation were associated with the expression of hs CRP and LPA in the hepatitis B group(all P < 0. 05). Moreover,clinical stage and histological differentiation were important factors influencing the expression of hs CRP and LPA(all P < 0. 05). Conclusion Compares with alcohol associated liver cancer,the expression of hs-CRP and LPA are highly expressed in hepatitis B associated liver cancer,which are associated with the clinicopathological features.