^125I组织问放疗联合介入治疗肝癌42例报告

目的探讨^125I放射性粒子组织间放疗联合肝动脉介入治疗肝肿瘤的疗效、可行性和安全性。方法2005年2月至2008年2月，对42例肝癌住院患者实施了放射性粒子^125I组织间放疗联合肝动脉介入治疗。其中肝细胞癌38例，胆管癌4例。病例均经CT、超声、MRI检查或病理穿刺活检证实。全部病灶在接受肝动脉介入治疗2周内，在CT、超声导向下将^125I放射性粒子植入肿瘤碘油栓塞区内及其周围，随之继续介入治疗1～2次。结果2个月后增强CT复查，完全缓解（CR）3例；部分缓解（PR）27例，无变化（NC）9例，进展（PD）3例，总有效率为71．4％。结论肝动脉介入治疗后联合CT导向下放射性粒子植入治疗肝脏肿瘤，并发症发生率低，治疗效果较二者单一治疗有所提高，是治疗肝脏肿瘤的一种有效方法。

^125I radioactive particle interstitial radiotherapy and hepatic artery interventional therapy in hepatoma

Objective To find ^125I radioactive particle interstitial radiotherapy and hepatic artery interventional therapy is feasible and safe to hepatoma. Methods Totally 42 patients with hepatoma were treated with ^125I radioactive particle interstitial radiotherapy and hepatic artery interventional therapy between February 2005 and February 2008. Thirty-eight of those is with hepatic cellular cancer. Four cases is with cholangiocarcinoma. Those eases were eomfirmed by CT or MRI or pathologic puncture biopsy. All patients received hepatic artery interventional therapy. After 2 weeks, we implanted radioactive particles by the aiming of CT or ultrasound in the periphery of lipiodol embolism. After this ,we have performed 1-2 cycles of interventional therapy. Results The clinical response rate was 71.4% （ CR ＋ PR）. Three cases get CR, 27 cases PR, 9 cases NC, 3 cases PD. Conclusions After hepatic artery interventional therapy, patients with hepatoma can benefit from implanting radioactive particles by aiming CT with small complications. The rate of therapeutic alliance elevates to any one therapy. Therapeutic alliance is effective in the tumor of liver.