2015—2019年某焦化厂下风向居民血清免疫球蛋白分析

目的： 比较2015—2019年某焦化厂下风向居民不同人群血清免疫球蛋白的含量并分析其变化趋势。方法： 2015—2019年夏季，选取中国北部某焦化厂下风向（1~2 km）两个村庄的常住居民为研究群体，按照一定的纳入排除标准确定研究对象，采集其血液及尿液通过全自动生化分析仪分别检测血清免疫球蛋白（IgG、IgA和IgM）含量及尿肌酐（Cr），并对血清免疫球蛋白含量异常率进行统计分析。尿液中多环芳烃代谢物1-羟基芘的含量采用高效液相色谱-荧光法检测。结果： 2015—2019年某焦化厂下风向居民中，女性血清IgG含量均值在各年份间均高于男性（P<0.01），IgM含量均值在2015年和2016年高于男性（P<0.05）；成人血清IgG和IgA含量均值在各年份间均高于未成年人（P<0.01），IgM含量均值在2016年低于未成年人（P<0.01）。2015—2019年某焦化厂下风向居民血清免疫球蛋白含量异常率总体呈先上升后下降的趋势，血清IgA和IgM在不同年份间的差异具有统计学意义（P<0.01），且2016年成人血清IgG、IgA和IgM含量异常率均高于未成年人（P<0.05），2015年和2016年女性血清IgG含量异常率高于男性（P<0.05）。2015—2019年，该地区居民尿液中多环芳烃代谢产物1-羟基芘的检出水平（用尿肌酐含量校正）中位数依次为0.468、0.797、0.678、0.169和0.021 μg/g。结论： 2015—2019年焦化厂下风向居民血清免疫球蛋白（IgG、IgA和IgM）含量具有一定的性别差异和年龄差异，其异常率总体呈现先上升后下降的趋势。

Analysis of serum immunoglobulins among residents in the downwind direction of a coking plant in from 2015 to 2019

OBJECTIVE: To compare serum immunoglobulin contents among different populations of residents in the downwind direction of a coking plant from 2015 to 2019 and to analyze changes in trends of abnormal rates. METHODS: In each summer from 2015 to 2019,residents from two villages in the downwind direction (1 to 2 km) of a coking plant in northern China were selected as the research group. They were recruited according to certain inclusion and exclusion criteria,and their blood and urine samples were collected to detect the contents of immunoglobulin (IgG,IgA and IgM) and urine creatinine (Cr) through an automatic biochemical analyzer. Abnormal rates of serum immunoglobulin contents were statistically analyzed. Contents of polycyclic aromatic hydrocarbon metabolite 1-hydroxypyrene in urine was detected by high performance liquid chromatography-fluorescence detection method. RESULTS: Among the research residents, the average serum IgG contents in women were higher than that of men for each year (P<0.01),and the average IgM contents were higher than that of men in 2015 and 2016 (P<0.05); The average serum IgG and IgA contents of adults were higher than those of minors in each year (P<0.01),while the average serum IgM content of adults was lower than that of minors in 2016 (P<0.01). In 2015-2019,the abnormal rates of serum immunoglobulin contents showed an overall upward trend and then a downward trend. There were significant differences in serum IgA and IgM between different years (P<0.01). And in 2016,the abnormal rates of serum IgG,IgA and IgM contents in adult were higher than those in minors (P<0.05). The abnormal rates of serum IgG contents in women were higher than that in men in 2015 and 2016 (P<0.05). In addition,from 2015 to 2019,the median detection levels of polycyclic aromatic hydrocarbon metabolite 1-hydroxypyrene in the urine of residents in this area were 0.468,0.797,0.678,0.169 and 0.021 μg/g,respectively. CONCLUSION: From 2015 to 2019,the serum immunoglobulin (IgG,IgA and IgM) levels of residents in the downwind direction of the coking plant showed certain gender and age differences,and their abnormal rates generally show an upward trend and then a downward trend.