新辅助化疗提高食管癌手术R0切除率的研究

 目的　探讨新辅助化疗提高食管癌手术R0切除率的可能性。方法　30例食管癌患者，其中鳞癌18例，腺癌10例，小细胞癌2例。术前新辅助化疗采用以紫杉醇联合铂类为主的方案，化疗后予以手术治疗。结果　化疗有效率（CR+PR）56.7 %（17／30），R0切除率100 %，吻合口瘘发生率3.3 %（1／30），无死亡病例。结论　新辅助化疗对提高食管癌手术R0切除率具有重要意义，对术后长期生存的影响有待进一步随访观察。

Effect of neoadjuvant chemotherapy on R0 resection rate of esophageal carcinoma

Objective To investigate the possibility of increasing R0 resection rate in esophageal carcinoma after neoadjuvant chemotherapy. Methods 30 patients underwent operation after neoadjuvant chemotherapy mainly by paclitaxel combined with cis-platinum, including 18 squamous carcinoma cases. 10 adenocarcinoma cases and 2 small cell carcinoma cases.Results In these 30 patients,the overall effective rate of neoadjuvant chemotherapy is 56.7%(17/30)(CR+PR),R0 resection rate is 100%,and the incidence rate of anastomotic leakage is 3.3%(1/30),without perioperative death.Conclusion The neoadjuvant chemotherapv is significant in improving the R0 resection rate in esophageal carcinoma,and the impact of long-term survival after surgery needs further follow-up.