鼻咽癌无瘤生存者的生存质量分析

 目的：本研究通过调查研究了解鼻咽癌(NPC)无瘤存活者的生存质量(QOL)，探索影响患者生存质量的因素。方法：收集中山大学肿瘤医院的230名鼻咽癌无瘤存活者的QOL-NPCQOL资料和人口学资料(性别、年龄、教育水平、婚姻状况、人均收入、方言、其它慢性病、临床分期、治疗方法、放疗疗程、放疗阶段)，使用t检验或方差分析比较不同基本资料患者的QOL，使用多因素方差分析筛选出影响患者各个维度QOL的因素。结果：心理精神QOL的影响因素有放疗阶段、放疗疗程、其它慢性病。放疗后>5年、1个疗程、无其它慢性病患者有较高的心理精神QOL。社会关系QOL的影响因素有放疗阶段和治疗方法；放疗后>5年，单纯放疗患者有较高的社会关系QOL。副作用QOL的影响因素有放疗阶段，放疗后>5年的患者有较低的副作用QOL。结论：应该关注接受放射治疗、放化疗、多个疗程、有其它慢性病的患者，采取针对性的预防干预措施，降低放疗对患者的损伤作用，减少放疗的副作用，提高患者的生存质量。

Quality of life analysis of nasopharyngeal carcinoma tumor-free survivors

Objective To evaluate the quality of life （QOL） of nasopharyngeal carcinoma （NPC） tumor- free survivors, and analyze the factors affecting the QOL of NPC patients. Methods The QOL and demographic variables （gender, age, education, marital status, income, dialects, concomitant chronic disease, clinical stage, treatment method, radiation course, and radiotherapy stages） were collected. ANOVA and t test were used to compare the QOL of NPC patients among different demographic variables. Multivariate ANOVA was used to select the influencing factors. Results The influencing factors of psychological QOL included radiotherapystage, radiation course and concomitant chronic disease. NPC patients had higher psychological domain QOL whose survival greater than five years, had a completed course of radiation, and without other diseases （P 〈 0.05）.The influencing factors of social QOL included radiotherapy stage and treatment method （Pc 0.05）. The influencing factors of side-effect QOL included radiotherapy stage（P 〈 0.05）. Conclusion The NPC tumor-free survivors who survival longer, have more course of radiation and with chronic diseases should be pay more attention. Prevention interventions should be preformed to reduce radiation injury to patients; side effects, and improve QOL of NPC tumor-free patients.