连续二次大剂量化疗联合活化的造血干细胞和免疫细胞移植治疗难治性非小细胞肺癌

在LAK细胞对胃癌细胞KATOⅢ的杀伤过程中,加入单克隆抗体MGb2能产生明显协同作用。推测此作用的原理是抗体依赖细胞介导的细胞毒性作用(ADCC)。此作用随着制备LAK细胞时白细胞介素2(IL-2)浓度的增加而增高,与LAK活性呈平行关系;制备LAK细胞时,IL-2的诱导时间既影响LAK活性,也影响相应的ADCC作用。

Double-Cycle high Dose Chemotherapy with Autologous Hematopoietic Stem Cells and Immunocytes Transplantation in Refractory Non Small Cell Lung Cancer

We treated 8 patients with refractory non small cell lung cancer by the method of double - cycle high dose chemotherapy with actwated autologous bone marrow, peripheral stem cell, and immunocytes trnsplantation which takes four months. Regimen consist of cyclophospamide 3600mg/m2, adriamycin 90mg/m2 , cisplatin 150mg/m2, and etoposide 900mg/m2 given in three days. The results showed that all the treated patients hematopoietic function recovered in twenty five days after transplantation and some of the patients' immune function recovered more quickly. 3 patients were abtained complete responses , 3 patients partial responses, and 1 patient no change 1 patient died after the double cycle treatment. This research suggests that usage of high dose chemotherapy can improve the treating effect of refractory non small cell lung cancer. It is necessary for the patient with disease to use the double cycle transplantation treatment. The treatment is safe.