申捷对放疗前后脑照射野内N-乙酰天门冬氨酸、胆碱及肌酸含量的影响

目的：利用磁共振波谱技术检测应用申捷（单唾液酸四己糖神经节苷钠）及放疗前后脑组织内N-乙酰天门冬氨酸、胆碱及肌酸含量变化，探讨申捷在预防及治疗早期放射性脑损伤中的作用。方法：将鼻咽癌患者随机分为两组，对照组给予放疗﹢肾上腺皮质激素；治疗组：放疗﹢肾上腺皮质激素﹢申捷。申捷为每日100mg，加入到生理盐水或5％葡萄糖水中静脉滴注。两组均于放疗前及放疗后2个月行颅脑MRI、MRS检查，并测定NAA/Cr和Cho/Cr值。结果：放疗结束后双颞叶NAA/Cr在对照组中明显下降（ P＝0.022），在治疗组中无明显下降（P＝0.949）。而Cho/Cr在对照组中明显升高（P＝0.031），在治疗组中无明显升高（P

The effect of monosialotetrahexosylganglioside sodium injection on the content of NAA,Cho or Cr in brain tissue before and after radiotherapy

Objective：To explore the preventive effect of monosialotetrahexosylganglioside sodium injection on the radiation encephalopathy by detecting the content of NAA,Cho,or Cr in brain tissue with magnetic resonance spec-troscopy（ MRS）. Methods：All 56 cases with nasopharyngeal carcinoma were divided into two groups：The control group were treated with single radiotherapy,the treatment group were teated with radiotherapy plus monosialotetrahexo-sylganglioside sodium injection. The content of NAA,Cho,or Cr in brain tissue were detected by magnetic resonance spectroscopy. Results：In control group,NAA/Cr was lower after radiotherapy than before in brain parenchyma（ P=0. 022）. Cho /Cr was higher after radiotherapy than before in brain parenchyma（P=0. 031）. However ,in treatment group,there＇s no significant diference in NAA/Cr（P=0. 949）and Cho /Cr（P=0. 178）after and before radiothera-py. Conclusion：Monosialotetrahexosylganglioside sodium injection can prevent the occur of radiation encephalapathy in the early stage.