胃癌患者血浆中Hsp90α的表达及其诊断价值

目的:探讨在胃癌患者血浆中热休克蛋白90α（Hsp90α)的表达情况，以及与CEA、CA199、CA242在胃癌诊断中的临床价值。方法:检测207例胃癌患者血浆中Hsp90α及相关标志物的浓度水平。分析Hsp90α在患者性别、年龄、胃癌分期、发病部位及术前术后分组中的统计学差异。Hsp90α与CEA、CA199、CA242的相关系数。结果:胃癌组血浆中Hsp90α水平显著高于健康对照组，比较存在统计学差异(P<0.05)。胃癌患者血浆中Hsp90α水平在性别、年龄分组中比较无统计学差异(P>0.05)；在分期分组中，高分期Hsp90α水平显著高于低分期，Ⅰ、Ⅱ与Ⅲ、Ⅳ期Hsp90α水平存在统计学差异(P<0.05)；发病部位不同，Hsp90α水平胃淋巴瘤>胃体癌>贲门癌，组间比较有统计学差异(P<0.05)；转移后Hsp90α水平显著高于未转移组，比较有统计学差异(P<0.05)。术前Hsp90α水平显著高于术后，比较有统计学差异(P<0.05)。Hsp90α与CEA、CA199、CA242的相关系数r=0.376、0.390、0.555(P<0.05)，说明血浆中Hsp90α与CEA、CA199、CA242均存在正相关性，在胃癌中可作为辅助诊断指标。结论:血浆中Hsp90α水平在胃癌中显著升高，在胃癌的早期筛查、诊断、鉴别和治疗中具有重要临床参考价值。

Expression and diagnostic value of plasma Hsp90α in gastric cancer patients

Objective:To investigate the expression of plasma heat shock protein 90α（Hsp90α) in gastric cancer and the clinical value in the diagnosis of gastric cancer.Methods:The blood concentrations of Hsp90α and related markers were detected in 207 patients with gastric cancer.The statistical differences of Hsp90α were analysed in patients' gender,age,gastric cancer staging,site of onset,preoperation and postoperation.Results:The level of plasma Hsp90α in gastric cancer group was significantly higher than that in healthy control group,with statistical difference(P＜0.05).There was no significant difference for plasma Hsp90α level in the gender and age groups of gastric cancer patients（P>0.05).In staging group,Hsp90α level in high stage was significantly higher than that of low stage,and Ⅰ,Ⅱ and Ⅲ,Ⅳ stage Hsp90α level had statistical differences（P<0.05).Hsp90α level in gastric lymphoma>gastric body cancer>gastric cardia cancer,the difference between groups was statistically significant（P<0.05).The Hsp90α level in metastasis group was significantly higher than non-metastasis group,with statistically significant difference（P<0.05).Preoperative Hsp90α level was significantly higher than postoperative Hsp90α level,with statistically significant difference（P＜0.05).The correlation between Hsp90α and CEA,CA199 and CA242 was r=0.376,0.390,0.555(P＜0.05),indicating that the plasma Hsp90α level was positively correlated with CEA,CA199,CA242,and can be used as an auxiliary diagnostic indicator in gastric cancer.Conclusion:Hsp90α is significantly increased in gastric cancer,which has important clinical reference value in early screening,diagnosis,differentiation and treatment of gastric cancer.