鲍温病中XB130的表达和意义及临床病理分析

目的:研究XB130在鲍温病皮损组织中的表达，探讨其在鲍温病发生发展过程中的作用，并探讨鲍温病的临床病理特点。方法:回顾性分析我院161例鲍温病的临床及病理资料并应用免疫组化法检测37例鲍温病组织及35例正常皮肤组织中XB130的表达情况。结果:鲍温病多发于老年人，无性别差异，但男性的平均确诊年龄低于女性，所有患者中躯干为最常见发病部位。XB130在鲍温病组织中表达降低， XB130在正常皮肤组织及在鲍温病中的阳性表达率及表达强度差异均有统计学意义（P＜0.05）。结论:鲍温病多发于老年人，无性别差异，男性患者发病普遍早于女性患者，所有患者中躯干为最常见的发病部位，女性患者头颈部发病最多见，男性则多发于躯干。XB130在鲍温病皮损中的表达明显低于正常皮肤组织，XB130可能参与鲍温病的发生与发展。

The expression and significance of XB130 in Bowen' s disease and the clinicalpathological observation

Objective:To investigate the expression and significance of XB130 in Bowen's disease and analyze the clinical pathological characteristics of the patients.Methods:Immunohistochemistry was carried out to detect the expression of XB130 in 37 patients with Bowen's disease and 35 specimens of normal skin.Retrospective analysis was conducted to analyze the clinical pathological characteristics of 161 patients with Bowen's disease.Results:There was no significant difference in sex ratioin 161 patients from 2012 to 2018,but the mean age of diagnosis of male and female patients was statistically different.The most common anatomical site of the patients was trunk.XB130 was down-regulated in Bowen's disease.The positive rate and expression intensity of XB130 were both statistically significant between normal skin and Bowen's disease (P＜0.05).Conclusion:The age of onset of males is earlier than that of females,but there is no difference in sex ratio.The high incidence age of patients is in the old age.Head and neck region was the anatomical site most frequently observed in female patients,whereas trunk was the most represented location in male patients.And the most common site of the overall patients was trunk.The expression of XB130 in Bowen's disease was significantly lower than that of normal skin.XB130 may be involved in the pathogenesis of Bowen's disease.