| 肿瘤外泌体对CD8+T细胞功能的影响及机制研究进展 |
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| 引用本文： | 樊小源,' target='_blank'>,张丽峰,冷 静,' target='_blank'>.肿瘤外泌体对CD8+T细胞功能的影响及机制研究进展[J].现代肿瘤医学,2021,0(21):3869-3873. |
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| 作者姓名： | 樊小源 ' target='_blank'> 张丽峰 冷 静 ' target='_blank'> |
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| 作者单位： | 1.广西中医药大学基础医学院，广西 南宁 530200;2.广西中医药大学广西高发传染病中西医结合转化医学重点实验室，广西 南宁 530200 |
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| 基金项目： | National Natural Science Foundation of China(No.81660753）;国家自然科学基金项目（编号:81660753）;广西自然科学基金项目（编号:2018GXNSFAA281031,2018GXNSFAA294100） |
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| 摘 要： | 外泌体（exosomes）是介导细胞间通讯的细胞外囊泡。它携带来源细胞的多种生物活性分子，并可将其输送给受体细胞，进而影响细胞功能。肿瘤来源外泌体可通过多种机制介导肿瘤的免疫逃逸。本文就肿瘤外泌体对肿瘤杀伤主力军CD8+T细胞的调控作用进行总结，分析其相关作用机制，以期为肿瘤免疫治疗的研发提供新的思路。
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| 关 键 词： | 肿瘤 外泌体 CD8+T细胞 |
Effect of tumor exosomes on the function of CD8+T cells and its mechanism |
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| FAN Xiaoyuan,' target='_blank'>,ZHANG Lifeng,LENG Jing,' target='_blank'>.Effect of tumor exosomes on the function of CD8+T cells and its mechanism[J].Journal of Modern Oncology,2021,0(21):3869-3873. |
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| Authors: | FAN Xiaoyuan ' target='_blank'> ZHANG Lifeng LENG Jing ' target='_blank'> |
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| Affiliation: | 1.School of Basic Medicine,Guangxi University of Traditional Chinese Medicine,Guangxi Nanning 530200,China;2.Key Laboratory of High Incidence Infectious Diseases,Guangxi University of Traditional Chinese Medicine,Guangxi Nanning 530200,China. |
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| Abstract: | Exosomes are extracellular vesicles that mediates intercellular communication.It carries a variety of bioactive molecules from the source cells and transports them to the receptor cells to regulate their functions.Tumor derived exosomes can mediate tumor immune escape through a variety of mechanisms.In this paper,the regulatory effects of tumor exosomes on CD8+T cells,the main tumor killer force were summarized and the relevant mechanism was analyzed,hoping to provide new ideas for the research and development of tumor immunotherapy. |
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| Keywords: | tumor exosomes CD8+T cells |
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