大肠癌患者血清基质金属蛋白酶-7含量的临床意义

目的:评估大肠癌患者血清MMP-7含量及其临床意义.方法:术前应用免疫酶联反应技术对50例大肠癌患者以及36例健康对照者的血清MMP-7含量进行检测,同时也检测这些患者血清CEA、CA19-9以及CA24-2含量.将大肠癌患者的血清MMP-7及其它肿瘤标志物的含量与健康对照者进行了比较.对不同临床病理分期的大肠癌患者血清MMP-7含量进行评估.结果:研究发现多数大肠癌患者的血清MMP-7含量升高.大肠癌患者的血清MMP-7含量,分布范围0.72-28.69ng/ml(平均4.41ng/ml;中位4.19ng/ml),显著高于健康对照者,分布范围0.69-3.97ng/ml(平均1.62ng/ml;中位1.36ng/ml)(P<0.01).大肠癌患者的血清MMP-7平均阳性率(46%)与CEA(30%),CA19-9(26%)及CA24-2(24%)相比均升高(P<0.05).进展期肿瘤患者血清MMP-7含量显著高于早期肿瘤患者(P<0.05).结论:血清MMP-7有可能成为大肠癌患者临床监测标志物.

Clinical significance of serum matrix metalloproteinases - 7 in patients with colorectal carcinoma

Objective: To evaluate serum levels of MMP -7 and its clinical significance in patients with colorectal carcinoma. Methods:MMP -7 in serum was examined prior to surgery on 50 patients with colorectal cancer as well as from 36 healthy normal controls by using a quantitative sandwich enzyme immunoassay technique, and serum carcino-embryonic antigen (CEA), CA19 -9 and CA24 -2 levels were also examined in the same patients. Serum MMP -7 levels in colorectal carcinoma patients were compared with other tumor markers as well as that in healthy controls. In addition, MMP-7 serum concentrations in patients with different clinicopathological stages of colorectal carcinoma were also evaluated. Results:The majority of the patients with colorectal carcinoma were found to have high concentrations of serum MMP -7. MMP -7 levels in patients with colorectal cancer, ranged from 0.72 -28.69ng/ml (mean, 4.41ng/ml; median, 4. 19ng/ml) , were significantly higher than levels in sera from healthy individuals, ranged from 0.69 to 3.97 ng/ml (mean, 1.62ng/ml; median, 1.36ng/ml) (P<0.01). The mean positive percentage of MMP -7 (46%) compared with CEA (30%) , CA19 -9 (26%) and CA24 -2 (24%) serum concentration being higher in colorectal patients (P<0. 05). MMP -7 serum concentrations of patients with advanced stage carcinoma were significantly higher compared to patients with early stage cancer (P <0.05). Conclusion;The present data indicate that the elevation of serum levels of MMP - 7 may be a useful marker for clinical monitoring of colorectal carcinoma patients.