| 乳腺浸润性导管癌组织Bmi-1的表达及其临床意义 |
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| 引用本文： | 张建兵,朱兴华,陈露,陈培战,何松,陆晓云,刘玉山.乳腺浸润性导管癌组织Bmi-1的表达及其临床意义[J].中华肿瘤防治杂志,2011,18(17):1363-1366. |
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| 作者姓名： | 张建兵 朱兴华 陈露 陈培战 何松 陆晓云 刘玉山 |
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| 作者单位： | 1. 南通大学附属肿瘤医院病理科,江苏南通,226361
2. 中国科学院上海生命科学研究院营养科学研究所,上海,200031 |
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| 基金项目： | 南通市社会发展科技计划项目(S2008013) |
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| 摘 要： | 目的:探讨Bmi-1在乳腺浸润性导管癌组织中的表达及其与临床病理特征的关系。方法:免疫组化法检测84例乳腺癌组织中雌激素受体(ER)、孕激素受体(PR)、c-erbB-2和B细胞特异性莫洛尼小鼠白血病病毒整合位点-1(Bmi-1)表达,并取其中43例(51.2%)乳腺癌新鲜肿瘤组织和癌旁的正常组织,采用RT-PCR方法检测其Bmi-1表达。结果:84例乳腺浸润性导管癌组织中Bmi-1蛋白阳性表达率为56.0%(47/84)。43例乳腺癌新鲜肿瘤组织中Bmi-1mRNA阳性表达率为67.4%(29/43)。Bmi-1过表达与临床晚期及ER阴性表达显著相关,P<0.05。Bmi-1表达与患者年龄、肿瘤大小、组织学分级以及PR、c-erbB-2表达均无明显相关性,P>0.05。Bmi-1在乳腺浸润性导管癌与癌旁正常组织中的表达差异有统计学意义,P<0.01。结论:Bmi-1过表达与乳腺浸润性导管癌的发生、发展有关。Bmi-1可能成为预测乳腺浸润性导管癌临床分期的新分子标志。
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| 关 键 词： | 乳腺肿瘤 蛋白质类 免疫组织化学 逆转录聚合酶链反应 |
Expression and clinicopathological relevance of Bmi-1 in invasive mammary ductal cancer |
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| ZHANG Jian-bing,ZHU Xing-hua,CHEN Lu,CHEN Pei-zhan,HE Song,LU Xiao-yun,LIU Yu-shan.Expression and clinicopathological relevance of Bmi-1 in invasive mammary ductal cancer[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(17):1363-1366. |
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| Authors: | ZHANG Jian-bing ZHU Xing-hua CHEN Lu CHEN Pei-zhan HE Song LU Xiao-yun LIU Yu-shan |
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| Affiliation: | ZHANG Jian-bing1,ZHU Xing-hua1,CHEN Lu2,CHEN Pei-zhan2,HE Song1,LU Xiao-yun1,LIU Yu-shan1 1.Department of Pathology,Affiliated Cancer Hospital of Nantong University,Nantong 226361,P.R.China 2.Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the relationship between the expression of Bmi-1 and clinicopathological characteristics in invasive mammary ductal cancer.METHODS: Immunohistochemistry was used to detect the expression of ER,PR,c-erbB-2 and Bmi-1 oncoproteins in 84 cases of invasive mammary ductal carcinoma.RT-PCR assay was used to detect the mRNA expression level of Bmi-1 in 43 cases(51.2% from the 84 cases) of breast cancer and paraneoplastic tissues.RESULTS: The positive rate of Bmi-1 oncoprotein expression was... |
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