脑转移瘤的X刀治疗与手术治疗疗效比较分析

目的 :探讨X刀在脑转移瘤治疗中的临床价值。方法 :回顾分析X刀治疗的 30例脑转移瘤患者 ( 4 1个病灶 ) ,脑转移瘤直径 ( 2 .0 7± 1.7)cm ,平均剂量 2 2Gy ,肿瘤中心剂量 ( 2 8± 8)Gy ,边缘剂量 ( 16± 4 )Gy。比较分析手术加全脑放射治疗 2 6例 ,直径 ( 3.0 7± 0 .7)cm ,平均放疗剂量 4 6Gy。结果 :X刀治疗组 1年生存率 53% ,手术加全脑放疗组 4 3% ,1年后局部肿瘤控制率分别为 83%和 75% ,1年后因神经系统疾患死亡率分别为 39%和 4 1%。结论 :X刀是一种安全、有效和微侵袭的治疗方法 ,适用于中小体积脑转移瘤的治疗

Comparison of X-knife Radiotherapy and Surgery in the Treatment of Brain Metastases

Objectlve To explore the clinical value of X-ray knife in the treatment of brain metastases.Methods 30 patients with brain metastases of 41 lesions treated by X-ray knife were analysed retrospectively,the diameters of the brain metastases were(2.07 ± 1 .7)cm,the mean dose given by X- ray knife was 22 Gy,the centraldoses were (28 ± 8 ) Gy, and the peripheral doses were ( 16 ± 4) Gy. 26 patients with brain metastasesreceived surgical resection combined with whole brain radiotherapy were analysed comparatively, the diametersof the lesions in the latter group were(3.07 ± 0.7)cm, and the mean whole brain radiation dose was 46 Gy. Re-sults The 1-year survival rate of patients in X-ray knife group was 53 %, and 43 % in the surgery group ( P =0.19). The 1-year local tumor control rates were 83 % and 75 % in the two groups, respectively (P = 0.49).The 1-year neurological disease-specific death rates were 39% and 41%, respectively. Conclusions X-rayknife is a safe, effective and minimally invasive treatment method for the small brain metastases.