| 恶性肿瘤中泛素化修饰对Warburg效应调控机制的研究进展 |
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| 引用本文： | 王凤丽,胡晶.恶性肿瘤中泛素化修饰对Warburg效应调控机制的研究进展[J].肿瘤防治研究,2022,49(6):616-622. |
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| 作者姓名： | 王凤丽 胡晶 |
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| 作者单位： | 150081 哈尔滨，哈尔滨医科大学附属肿瘤医院内四科 |
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| 基金项目： | 国家自然科学基金面上项目(81972162)；;黑龙江省自然科学基金优秀青年项目(YQ2019H026)；;黑龙江省博士后科研启动资助基金项目(LBH-Q19042)； |
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| 摘 要： | 泛素化和Warburg效应在肿瘤的发生发展中均发挥重要作用。肿瘤中泛素化修饰过程与糖酵解效应密切相关，即肿瘤细胞中的泛素化修饰作用能够调控Warburg效应相关的底物蛋白的表达水平，进而调控肿瘤进展和治疗耐药。本文着重讨论肿瘤细胞中蛋白质的泛素化修饰作用对Warburg效应的调控机制。
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| 关 键 词： | 泛素化 糖酵解 Warburg效应 缺氧微环境 肿瘤 |
| 收稿时间： | 2021-10-08 |
Research Progress on Regulatory Mechanism of Ubiquitin Modification on Warburg Effect in Malignant Tumors |
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| WANG Fengli,HU Jing.Research Progress on Regulatory Mechanism of Ubiquitin Modification on Warburg Effect in Malignant Tumors[J].Cancer Research on Prevention and Treatment,2022,49(6):616-622. |
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| Authors: | WANG Fengli HU Jing |
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| Affiliation: | The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China |
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| Abstract: | Ubiquitin modification and Warburg effect play an important role in the occurrence and development of tumors. The process of tumor ubiquitin modification is closely related to glycolysis, that is, ubiquitin modification in tumor cells can regulate the expression level of substrate proteins related to Warburg effect, then regulate tumor progression and the treatment of drug-resistance. This paper reviews the regulation mechanism of ubiquitin modification of proteins on Warburg effect in tumor cells. |
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| Keywords: | Ubiquitin Glycolysis Warburg effect Hypoxic microenvironment Cancer |
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