头颈部恶性肿瘤嗜神经侵袭临床诊治现状

嗜神经侵袭是肿瘤通过神经扩散与转移的一种独特的生物学行为,与复发、转移、预后密切相关。随着研究的不断深入,人们普遍认识到嗜神经侵袭的临床意义。但由于头颈部肿瘤发病率相对较低,不同解剖部位、不同病理类型嗜神经发生率各不相同,故缺乏高级别的循证医学证据。目前嗜神经侵袭的病理学机制尚未完全阐明,也无针对神经侵犯的特异性治疗手段,因此头颈部肿瘤嗜神经侵袭的治疗对于临床医师是一个巨大的挑战。本文就头颈部恶性肿瘤中嗜神经侵袭的临床诊治现状做一综述。

Clinical diagnosis and treatment of perineural invasion of head and neck malignant tumors

Perineural invasion is a unique biological behavior of tumors via nerve dissemination and metastasis,which is intimately correlated with the recurrence,metastasis and prognosis. With the deepening research, the clinical significance of perineural invasion has been widely recognized. However,due to the low incidence of head and neck neoplasms and the varying incidence of perineural invasion in different anatomical sites and pathological types,high-level evidence-based medical evidence is still lacking. Currently,the pathological mechanism of perineural invasion has not been clearly clarified. No specific treatment has been available for perineural invasion. Therefore,the treatment of perineural invasion of head and neck tumors is an enormous challenge for clinicians. In this article, the current status of clinical diagnosis and treatment of perineural invasion in head and neck malignancies was reviewed.