泰素治疗妇科恶性肿瘤临床观察

目的　观察泰素治疗妇科肿瘤的疗效。方法　以泰素治疗妇科恶性肿瘤 37例 ,其中卵巢肿瘤 2 7例 ,输卵管癌 6例 ,宫颈癌 3例 ,宫内膜癌 1例。 33例为术后或化疗后复发病例 ,4例为原发卵巢癌。对照组为相应时间内复发的 37例妇科恶性肿瘤 ,其中卵巢癌 30例 ,输卵管癌 4例 ,宫颈癌 2例 ,宫内膜癌 1例。泰素化疗前 6 ,12h给预防用药地塞米松、希米替丁、苯海拉明。化疗前 0 5h给地塞米松 止吐药 (灭吐灵或康泉 )。然后泰素 135～ 15 0mg/m2 静注 3h(或腹腔灌注 )。联合化疗 顺铂 环磷酰胺。对照组采用PAC(顺铂 环磷酰胺 表阿霉素 )及VBP方案 (长春新碱 平阳霉素 顺铂 )。结果　泰素化疗组与对照组中位生存期分别为 8.5个月和 4个月。有效率 (CR PR)分别为48.6 %与 18.8% (P <0 .0 0 1,P <0 .0 5 ) ,差异有显著性。化疗毒副反应主要是骨髓抑制与脱发。结论妇科恶性肿瘤中 ,卵巢癌治疗疗效差 ,易复发。泰素 /治疗卵巢癌及输卵管癌疗效好 ,毒副反应较轻。

Clinical observation of palitaxel in the treatment of gynecologic malignant tumors

OBJECTIVE: To observe the therapeutic effect of palitaxel. METHODS: Of 37 cases, 33 were treated when tumor recurrence occurred after surgery or chemotherapy. There were 27 cases with ovarian cancer, 6 with fallopian tube cancer. 3 with cervix cancer, and 1 with endometrium cancer. In all cases, diagnosis was confirmed by histopathology. Palitaxel (135-150 mg/m2) was administered i.v. or i.p. once every three werks in combination with cisplatin (PDD) 60 mg/m2 and cyclophosphamide (CTX) 60 mg/d. Antihistaminics and antiemetic were given prior to palitaxel. The results of treatment were compared with those in 37 cases treated in the some time period with PAC or VBP regimen. RESULTS: The overall median survival time of the control group was 4 months, and 8.5 months in the palitaxel treated group (P < 0.001). The response rate was 18.9% and 48.6% respectively (P < 0.005). The major toxic effects was myelosuppression and alopecia. CONCLUSION: Palitaxel is effective in the treatment of advanced gynecological tumors.