顺铂加长春酰胺配合外照射治疗晚期鼻咽癌的临床研究

目的 观察放化综合治疗晚期鼻咽癌的疗效，方法 ６４例Ｎ２￣Ｎ３晚期鼻咽癌患者随机分为综合组（放疗＋化疗）和单纯放疗组，综合组放疗前后采用化疗方案；顺铂３０ｍｇ／日，连续５天，长春酰胺（Ｖｉｎｄｅｓｉｎｅ，西艾克，ＶＤＳ）３ｍｇ／ｍ＾２，第１天，第７天，两组放疗方法，剂量相同。结果综合组，单纯放疗组在放疗４０Ｇｙ和放疗结束后３个月，颈淋巴结消退率分别为４３．８％、８７．５％和２８．１％、７５．０％（

Clinical study of advanced nasopharyngeal carcinoma treated with radiotherapy combined with DDP and vindesine

OBJECTIVE: To evaluate the result of radiotherapy combined with chemotherapy for advanced nasopharyngeal carcinoma (NPC). METHODS: From August 1996 to October 1997, 64 cases of advanced NPC (stage N2-N3) patients were randomized to receive radiotherapy (RT) alone or RT combined with 2 cycles of chemeotherapy (CT) (cisplatin, vindesine). Thirty two patients were assigned to CT + RT, and 32 to RT alone. RESULTS: At 40 Gy of RT the response rate was 28.1% in RT group and 43.8% in CT + RT group. The response rate at 3 months after RT was 75.0% in RT group and 84.4% in CT + RT group (P < 0.05). The major toxic effects were gastrointestinal reaction, myelosuppession and alopecia. CONCLUSION: Chemotherapy with cisplatin and vindesine before and after radiotherapy increases the response rate of advanced NPC with lymph node metastases.