首页 | 官方网站   微博 | 高级检索  
     

多西紫杉醇联合奥沙利铂和5-氟尿嘧啶双周方案治疗晚期胃癌的初步研究
作者姓名:Wang ZH  Guo J  Chen Z  Li CZ  Sheng LJ  Zhou DG  Liu B  Liu J  Wang QC  Zhang EN
作者单位:1. 山东省肿瘤医院内科,济南,250117
2. 泰安市人民医院消化内科
3. 烟台市肿瘤医院内科
摘    要:目的 探讨多西紫杉醇(DOC)联合奥沙利铂(L-OHP)和5-氟尿嘧啶(5-Fu)的DOF双周方案对晚期胃癌的临床疗效和毒副反应.方法 37例晚期胃癌患者均行锁骨下深静脉穿刺或外周肘正中静脉穿刺,置入单腔输液导管,经电脑输液泵控制5-Fu的输液速度.DOC 35 mg/m2, 静脉滴注1 h,第1天;L-OHP 85 mg/m2,静脉滴注2 h,第1天;甲酰四氢叶酸(LV) 200 mg/m2,静脉滴注2 h,第1天;5-Fu 1500 mg/m2,持续静脉滴注48 h,第1~2天.14 d为1个周期,至少应用3个周期进行疗效评估.结果 全组37例均可评价疗效,总有效率为67.6%,其中完全缓解率为27.0%,部分缓解率为40.5%.至肿瘤进展时间为9.2个月,中位生存期为13.7个月.在初次化疗的11例患者中,有效率为81.8%;在既往接受过化疗的26例患者中,有效率为61.5%.主要剂量限制性毒性反应为骨髓功能抑制,其中Ⅲ~Ⅳ度白细胞下降率为29.7%,无治疗相关性死亡. 结论 DOF双周方案是晚期胃癌的有效化疗方案,其毒副反应轻微,患者易于耐受,值得进一步研究.

关 键 词:胃肿瘤  多西紫杉醇  奥沙利铂  5-氟尿嘧啶  化疗

Preliminary study of biweekly regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer
Wang ZH,Guo J,Chen Z,Li CZ,Sheng LJ,Zhou DG,Liu B,Liu J,Wang QC,Zhang EN.Preliminary study of biweekly regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer[J].Chinese Journal of Oncology,2008,30(5):389-391.
Authors:Wang Zhe-Hai  Guo Jun  Chen Zhen  Li Chang-Zheng  Sheng Li-Jun  Zhou Deng-Guang  Liu Bo  Liu Jie  Wang Qing-Cai  Zhang En-Ning
Affiliation:Department of Medical Oncology, Shandong Cancer Hospital, Jinan 250117, China. wzhai8778@sina.com
Abstract:Objective To evaluate the efficacy and toxicity of a biweekly DOF regimen consisting of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer. Methods The biweekly DOF regimen was administered in 37 advanced gastric cancer patients. Docetaxel, oxaliplatin and leucovorin were given intravenously at a dose of 35 mg/m2, 85 mg/m2 and 200 mg/m2 for 1 h, 2 h and 2 h on D1, respectively, and 5-Fu was administered as continuous intravenous infusion for 48 h at a dose of 1500 mg/m2 on D1 and D2. This regimen was repeated every 2 weeks. The efficacy and toxicity were evaluated after completion of 3 cycles at least. Results The overall response rate (RR) of this series was 67.6%, complete response rate and partial response rate were 27.0% and 40.5%, respectively. The time to progression (TTP) was 9.2 months, and median survival time (MST) was 13.7 months. The RRs of 11 chemotherpy-nave patients and 26 patients pre-treated with chemotherapy were 81.8% and 61.5%, respectively. Conclusion Our preliminary results showed that this biweekly combination regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin is effective and tolerable for advanced gastric cancer. However, further investigation of this regimen is mandatory.
Keywords:Gastric neoplasms  Docetaxel  Oxaliplatin  5-fluorouracil  Chemotherapy
本文献已被 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号