| Affiliation: | 1. Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA;2. Lois C.A. and Darwin E. Smith Distinguished Chair, Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA;1. Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;2. Gustave Roussy, Villejuif, France;3. INSERM, U1015, Villejuif, France;4. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;5. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;6. Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France;1. Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland;2. Institute of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland;3. Division of Endocrinology and Diabetes, Department of Internal Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland;4. Department of Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland;5. Department of Nuclear Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland;6. Clinical Trials Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland;7. Cancer Registry Eastern Switzerland, St. Gallen, Switzerland;1. Midwifery Master Study Programme, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia;2. Department of Radiology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia;3. Division of Fertility, Endocrinology and Reproduction, Department of Obstetric and Ginaecology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia |
| Abstract: | BackgroundChronic lymphocytic thyroiditis (CLT) frequently coexists with papillary thyroid carcinoma (PTC) that exhibits normal thyroid function. However, few studies have investigated the relationship between CLT and clinically lymph node (LN)-negative PTC. The aim of this study was to evaluate the relationship between subclinical central LN metastasis and CLT, and to assess the impact of CLT on the recurrence of clinically LN-negative PTC.MethodsWe investigated the medical records of 850 patients with PTC who underwent prophylactic bilateral central neck dissection as well as total thyroidectomy between 2004 and 2010; the median follow-up time was 95.5 months (range, 12–158 months).ResultsCLT was observed in 480 patients (56.5%). Female sex, a preoperative thyroid-stimulating hormone level >2.5 mU/L, a primary tumor ≤1 cm, no gross extrathyroidal extension, high number of harvested LNs, low number of metastatic LNs, and positive anti-thyroglobulin (Tg) antibody at 1 year post-initial treatment were significantly associated with the presence of CLT. Multivariate analysis revealed that patients with N1a stage (vs. N0 stage; hazard ratio HR], 3.255; 95% confidence interval CI], 1.290–8.213; p = 0.012) and positive anti-Tg antibody at 1 year post-initial treatment (vs. negative anti-Tg antibody; HR, 5.118; 95% CI, 2.130–12.296; p < 0.001) had poorer recurrence-free survival (RFS), while those with CLT (vs. no CLT; HR, 0.357; 95% CI, 0.157–0.812; p = 0.014) had favorable RFS outcomes.ConclusionsCLT is associated with less aggressive tumor characteristics and LN metastasis. Clinically LN-negative PTC patients with CLT experience longer RFS intervals than those without CLT. |
