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The 870G>A Polymorphism of the Cyclin D1 Gene is not Associated with Breast Cancer |
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| Authors: | Peter Krippl Uwe Langsenlehner Wilfried Renner Babak Yazdani-Biuki Gerald Wolf Thomas C Wascher Bernhard Paulweber Werner Weitzer Andreas Leithner Hellmut Samonigg |
| Affiliation: | (1) Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, 210029, China;(2) Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 210029, China;(3) Department of Epidemiology and Biostatistics, Cancer Center of Nanjing Medical University, 140 Hanzhong Rd., Nanjing, 210029, China; |
| Abstract: | A common 870G > A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility. To analyze its role for breast cancer, we determined the CCND1 genotype in 500 breast cancer patients and 500 controls. CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G > A polymorphism is not associated with breast cancer. |
| Keywords: | breast cancer cyclin D1 epidemiology gene polymorphism genetics |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |
