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Helicobacter pylori Risk Associated with Sibship Size and Family History of Gastric Diseases in Japanese Adults
Authors:Shogo Kikuchi  Michiko Kurosawa  Tsuguo Sakiyama
Affiliation:Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421;Clinic Attached to Kanto-shin-etsu Regional Taxation Bureau, 1-1-15 Kudan-minami, Chiyoda-ku, Tokyo 102-0074
Abstract:Helicobacter pylori is thought to be a cause of gastric cancer. Risk factors of H. pylori positivity were investigated among 4,361 public service workers in Japan. Sera and information on family history and lifestyle were collected, and H. pylori antibody was measured using the sera. Sex- and age-adjusted odds ratios of factors expected to influence H. pylori seropositivity were calculated. The factors with a significant influence were included in a logistic regression model and the final model was obtained by backward elimination. Sibship size (4 and more vs. 1), smoking habit (current vs. never), and paternal and siblings' histories of gastric diseases showed significant relationships to H. pylori seropositivity, with odds ratios (95% confidence intervals) of 1.5 (1.0–2.1), 0.8 (0.7–0.9), 1.5 (1.3–1.8) and 1.7 (1.1–2.6) respectively. However, spouse's history was not related. In the final model, sibship size and paternal history remained as positive factors, and smoking as a negative one. Contradictory results on the relationship between H. pylori status and smoking among recent studies indicate the existence of hidden confounding factors. It is suggested that infection from family members in childhood considerably affects the H. pylori status of Japanese adults, whereas infection between adults is rare.
Keywords:Helicobacter pylori            Family history  Sibship size  Serology  Epidemiology
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