| BC369对白血病造血祖细胞的体外药敏实验研究 |
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| 引用本文： | 张炳团,李崇渔.BC369对白血病造血祖细胞的体外药敏实验研究[J].中国癌症杂志,1997,7(1):53-54. |
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| 作者姓名： | 张炳团 李崇渔 |
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| 作者单位： | 湖北省襄凡市中心医院，同济医科大学 |
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| 基金项目： | 中国科学院“八五”重点项目中国科学院“八五”重点项目 |
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| 摘 要： | 目的研究ＢＣ３６９直接抑制或杀伤白血病造血祖细胞的作用。方法采用白血病造血祖细胞体外培养，分别设立ＢＣ３６９实验组和生理盐水对照组，然后同时放入ＣＯ２孵育箱中培养，６天后对比计算ＢＣ３６９的杀伤率。结果急性淋巴细胞白血病平均杀伤率为４９．３５％（Ｐ＜０．０１）；急性粒细胞白血病平均杀伤率为５７．４３％（Ｐ＜０．０１）；慢性粒细胞白血病平均杀伤率为４９．４８％（Ｐ＜０．０１）；多发性骨髓瘤杀伤率为１９．０３％（Ｐ＞０．０５）。结论ＢＣ３６９对１４例白血病患者骨髓造血祖细胞集落形成单位（Ｌ－ＣＦＵ）进行体外药敏实验；ＢＣ３６９对白血病细胞具有直接杀伤作用，其平均杀伤率为５１．２６％（Ｐ＜０．０１）。
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| 关 键 词： | BC_（369） 白血病 杀伤率 |
IN VIVO EXPERIMENT OF DRUG SENSITIVITY OF BC 369 ON LEUKEMIA ANCESTRAL BLOOD FORMING CELLS |
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| Zhang Bingtuan,Li Zhongyu ,Yuan Qing.IN VIVO EXPERIMENT OF DRUG SENSITIVITY OF BC 369 ON LEUKEMIA ANCESTRAL BLOOD FORMING CELLS[J].China Oncology,1997,7(1):53-54. |
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| Authors: | Zhang Bingtuan Li Zhongyu Yuan Qing |
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| Affiliation: | Zhang Bingtuan,Li Zhongyu *,Yuan Qing * |
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| Abstract: | PURPOSE To study the inhibitory or lethal action of BC 369 on leukemia ancestral blood forming cells. METHODS In vitro culture of leukemia ancestral blood forming cells were divided into two groups:BC 369 experimental group and physiological saline control group,together with CO 2 and put into an incubator.After 6 days,the lethality rate was calculated as compared to the control. RESULTS For acute lymphocytic leukemia,the mean lethality rate was 49 35%( P <0 01),while for acute granulocytic leukemia,it was 57 43% ( P <0 01),and for chronic granulocytic leukemia,it was 49 48% ( P <0 01),for multiple myeloma it was 19 03%( P <0 01). CONCLUSIONS BC 369 had a direct lethal action on leukemic cells,with a mean lethality rate of 51 26% ( P <0 01). |
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| Keywords: | BC 369 leukemia lethality rate |
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