肿瘤休眠期细胞的研究进展

肿瘤休眠是肿瘤发展中的一个阶段。处于肿瘤休眠阶段中，患者无明显的临床症状。肿瘤休眠期细胞可能出现在肿瘤早期、微转移期和肿瘤微残留中。肿瘤休眠期细胞能在静止阶段和增殖阶段之间转换，可能是肿瘤转移和复发的原因。目前对该转换的机制尚不明确，可能涉及血管生成、免疫应答、微环境中的各类因子和信号通路等。对肿瘤休眠期细胞进一步的研究可提供针对肿瘤转移和复发的治疗策略，对临床和科研具有重大意义。

Progression of dormant cell in cancer research

Tumor dormancy is a stage of tumor development. In this stage, patients don＇t exhibit significant clinical symptoms. Tumor dormant cells may arise in early stage of tumor development, micrometastases period and minimal residual. The tumor dormant cells can switch between the quiescent stage and proliferative stage, which is considered the cause of tumor metastasis and recurrence. However, the mechanism of this switch is still largely unknown. The elements involved in the switch regulation include unique expres- sion patterns, immune response, and a variety of factors and signaling pathways in the microenvironment. Further study of tumor dor- mant cells may provide a therapeutic strategy for tumor metastasis and tumor recurrence, which is of great significance to clinical activi- ty and research.