The effect of metabolic surgery on nonobese patients (BMI<30 kg/m2) with type 2 diabetes: a systematic review |
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Authors: | Zhi-Ping Huang Yan Guo Chao-Qian Liu Lin Qi Da-Jin Zou Wei-Ping Zhou |
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Affiliation: | 1. Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, People’s Republic of China;2. Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai, People’s Republic of China;3. Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, People’s Republic of China;4. Department of Orthopaedics, the Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China |
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Abstract: | BackgroundThe influence of metabolic surgery on the glucose and lipid profiles of nonobese body mass index<30 kg/m2 patients with type 2 diabetes, particularly the effect ≥1 year, remains unknown.MethodsPubMed and Ovid Embase were used.SettingUniversity hospitals.ResultsIn total, 21 studies including 921 patients were examined in this systematic review, the results of which revealed decrease in body mass index, waist circumference, fasting plasma glucose, glycosylated hemoglobin A1C, fasting C-peptide, fasting insulin, homeostasis model of assessment for insulin resistance index, triglycerides, total cholesterol, and low-density lipoprotein cholesterol. An increase in high-density lipoprotein cholesterol was also observed. The diabetes remission rates ranged from 13.3% to 90.2% according to 20 studies. The incidence of gastrointestinal bleeding ranged from 1% to 10% according to 9 studies. Four studies reported anemia after Roux-en-Y gastric bypass or one-anastomosis gastric bypass, with the incidence ranging from 8% to 33%.ConclusionsNonobese patients can achieve improvements in weight-related indices and glucose and lipid profiles in the short and medium term after metabolic surgery; however, the complications of metabolic surgery warrant further attention. |
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Keywords: | Metabolic surgery Nonobese Type 2 diabetes |
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