乌司他丁对重度烧伤患者SIRS发生率和氧化应激因子水平的影响

目的:研究乌司他丁对重度烧伤患者全身炎症反应综合征(Systemic inflammatory response syndrome,SIRS)发生率和氧化应激因子水平的影响。方法:选取笔者医院2016年4月-2018年7月收治的重度烧伤患者82例,根据治疗方法不同分为两组。对照组给予清洗、补液、抗感染、抗休克及加强营养支持等基本治疗,观察组在对照组基础上给予乌司他丁治疗。分析两组患者治疗后的SIRS发生率及丙二醛(Malonaldehyde,MDA)、脂质过氧化物(Lipid peroxide,LPO)、髓过氧化物酶(Myeloperoxidase,MPO)、白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-10(Interleukin-10,IL-10)表达水平。结果:观察组患者住院时间为(16.98±4.27)d短于对照组的(23.25±5.11)d,差异具有统计学意义(t=6.029,P=0.000)。两组治疗前MDA、LPO、MPO、IL-2、IL-10水平比较,差异不具有统计学意义(P>0.05)。观察组治疗3d、5d、7d后MDA、LPO、MPO水平低于对照组,IL-2、IL-10水平高于对照组,差异有统计学意义(P<0.05)。观察组入院3d、7d时SIRS发生率低于对照组,差异有统计学意义(P<0.05)。结论:乌司他丁应用于重度烧伤患者可调节IL-2、IL-10的表达水平,抑制氧化应激反应,减少SIRS发生率,缩短住院时间,加速患者康复。

Effect of Ulinastatin on the Incidence of SIRS and the Level of Oxidative Stress Factors in Patients with Severe Burn

Objective To study the effect of ulinastatin on the incidence of systemic inflammatory response syndrome (SIRS) and oxidative stress factors in patients with severe burn.Methods 82 patients with severe burn were selected from April 2016 to July 2018,and two groups were divided into two groups according to the treatment method.The control group was given the basic treatment of cleaning,fluid infusion,anti-infection,anti-shock and strengthening of nutritional support.The observation group was treated by Ulinastatin on the basis of the control group.The incidence of SIRS and the expression of malonaldehyde (MDA),lipid peroxide (LPO),myeloperoxidase (MPO),interleukin-2 (IL-2),interleukin-10 (IL-10) in the two groups were analyzed.Results The hospital stay time in the observation group was (16.98±4.27)d shorter than that in the control group(23.25±5.11)d,the difference was statistically significant(t=6.029,P=0.000).There was no significant difference in MDA,LPO,MPO,IL-2 and IL-10 levels between the two groups before treatment(P>0.05).The levels of MDA,LPO and MPO in the observation group were lower than those in the control group,and the levels of IL-2 and IL-10 were higher than those in the control group(P<0.05).The incidence of SIRS in the observation group was lower than that in the control group on the 3rd and 7th day after admission(P<0.05).Conclusion Ulinastatin can regulate the expression of IL-2 and IL-10,inhibit oxidative stress,reduce the incidence of SIRS,shorten the length of stay and accelerate the recovery of patients with severe burn.