The role of Wnt/mTOR signaling in spinal cord injury |
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| Affiliation: | 1. Department of Spine Surgery, LanZhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730000, PR China;2. Department of Spine Surgery, Ganzhou People''s Hospital, 16 Meiguan Avenue, Ganzhou, 342800, PR China;1. Department of Orthopaedic and Traumatology, British Hospital of Buenos Aires, Buenos Aires, Argentina;2. Scientific Advisory Committee, British Hospital of Buenos Aires, Buenos Aires, Argentina;1. Holy Spirit Hospital, Andheri, Mumbai, India;2. Criticare Superspeciality Hospital, Andheri, Mumbai, India;3. Meril Life Sciences, Mumbai, India;4. Upasani Superspeciality Hospital, Mulund, Mumbai, India;5. Holy Spirit Hospital, Andheri, Mumbai, India;6. PD Hinduja Hospital (Khar), Khar West, Mumbai, India;1. Southport and Ormskirk NHS Trust, Southport, PR8 6PN, UK;2. University of Manchester, Manchester, M13 9PL, UK;1. Department of Orthopaedics, Government Medical College and Hospital, Dindigul, Tamil Nadu, India;2. Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India;3. Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India;4. Fellow in Orthopaedic Rheumatology, Dr. RML National Law University, Lucknow, Uttar Pradesh, India;5. Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India;6. Department of Orthopaedics, Sanjay Gandhi Institute of Trauma & Orthopaedics, Bengaluru, Karnataka, India |
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| Abstract: | Spinal cord injury (SCI) is the most common disabling spinal injury, a complex pathologic process that can eventually lead to severe neurological dysfunction. The Wnt/mTOR signaling pathway is a pervasive signaling cascade that regulates a wide range of physiological processes during embryonic development, from stem cell pluripotency to cell fate. Numerous studies have reported that Wnt/mTOR signaling pathway plays an important role in neural development, synaptogenesis, neuron growth, differentiation and survival after the central nervous system (CNS) is damaged. Wnt/mTOR also plays an important role in regulating various pathophysiological processes after spinal cord injury (SCI). After SCI, Wnt/mTOR signal regulates the physiological and pathological processes of neural stem cell proliferation and differentiation, neuronal axon regeneration, neuroinflammation and pain through multiple pathways. Due to the characteristics of the Wnt signal in SCI make it a potential therapeutic target of SCI. In this paper, the characteristics of Wnt/mTOR signal, the role of Wnt/mTOR pathway on SCI and related mechanisms are reviewed, and some unsolved problems are discussed. It is hoped to provide reference value for the research field of the role of Wnt/mTOR pathway in SCI, and provide a theoretical basis for biological therapy of SCI. |
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| Keywords: | Wnt signaling mTOR Spinal cord injury (SCI) Cascade reaction Therapeutic target |
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