| 慢性肾衰竭患者白细胞介素13水平及血液透析对其影响 |
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| 引用本文： | 刘海燕,陈孝文,江黎明,唐德燊,梁东,刘华锋,许勇芝.慢性肾衰竭患者白细胞介素13水平及血液透析对其影响[J].中国中西医结合肾病杂志,2003,4(5):259-261. |
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| 作者姓名： | 刘海燕 陈孝文 江黎明 唐德燊 梁东 刘华锋 许勇芝 |
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| 作者单位： | 1. 广东医学院肾脏病研究所,湛江,524001
2. 广东医学院附属医院中心实验室,湛江,524001 |
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| 基金项目： | 广东省自然科学基金资助项目 (No .0 0 15 3 4)，广东省卫生厅基金资助项目 (No .B2 0 0 10 81) |
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| 摘 要： | 目的：探讨慢性肾衰竭(CRF)不同损害期患血浆白细胞介素13(IL—13)水平和临床意义以及血液速析(HD)对其影响。方法：应用酶联免疫吸附试验(ELISA)检测CRF患血浆IL—13水平对IL不同肾功能损害期患血浆IL—13水平，并与肌酐清除率(Ccr)做直线相关分析，观察HD对尿毒症患血浆IL—13水平的影响。结果：CRF患血浆IL—13水平较正常对照组增高，且随着肾功能损害程度的加重而增高，至尿毒症期达到最高，与Ccr呈负相关；初次HD使尿毒症患血浆IL—13水平降低，维持HD2个月后，血浆IL—13水平降低更为明显。结论：IL—13可能参与CRF患免疫炎症调节进程，HD可使其水平降低。
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| 关 键 词： | 慢性肾衰竭 白细胞介素13 血液透析 影响 |
| 修稿时间： | 2002年5月15日 |
Plasma Levels of Interleukin-13 in Patients with Chronic Renal Failure and the Effects of Hemodialysis on its Levels |
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| LIU Haiyan,CHEN Xiaowen,JIANG Liming,et al Institute of Nephrology,Affiliated Hospital of Guangdong Medical College,Zhanjiang.Plasma Levels of Interleukin-13 in Patients with Chronic Renal Failure and the Effects of Hemodialysis on its Levels[J].Chinese Journal of Integrated Traditional and Western Nephrology,2003,4(5):259-261. |
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| Authors: | LIU Haiyan CHEN Xiaowen JIANG Liming Institute of Nephrology Affiliated Hospital of Guangdong Medical College Zhanjiang |
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| Abstract: | Objective:To study the plasma levels of Interleukin-13 and clinical meaning of it(IL-13)in patients with chronic renal failure(CRF)and the effects of hemodialysis(HD)on IL-13 levels.Methods:ELISA was used to examine plasma levels of IL-13 in patients with CRF including various phases.Results:Plasma levels of IL-13 in patients with CRF were significantly higher than that in control group. Plasma levels of IL-13 were gradually increased with by renal damaging aggravation, and correlated negatively with Ccr. Plasma levels of IL-13 in uremia group were decreased after the first HD, and decreased even more after two months of continual HD.Conclusion:IL-13 may play an important role in immune and inflammatory regulation in CRF. HD could effect on the plasma levels of IL-13 in CRF. |
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| Keywords: | Chronic renal failure Interleukin-13 Hemodialysis |
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