结直肠高度恶性腺癌的临床病理特点和预后分析

目的 比较三种结直肠高度恶性腺癌(印戒细胞癌、黏液腺癌与低分化腺癌)的临床病理特点及预后.方法 对医科院肿瘤医院1988-2006年收治的有完整随访资料的148例结直肠黏液腺癌、55例印戒细胞癌和281例低分化腺癌的临床病理特点进行回顾性分析.应用SPSS13.0软件进行统计学分析,采用x2检验分析其相关因素,Kaplan-Meier法进行生存分析,Log-rank检验进行统计学比较.结果 结直肠印戒细胞癌、黏液腺癌和低分化腺癌在性别、发病年龄、肿瘤部位、有无肠梗阻、手术方式、脉管瘤栓、浸润深度、淋巴结转移和分期方面差异具有统计学意义(x2=7.67,38.4,86.0,14.5,93.7,17.3,62.1,24.4,56.17,P<0.05),印戒细胞癌中位生存期为24个月,黏液腺癌中位生存期为47个月,低分化腺癌中位生存期为49个月,差异有统计学意义(x2=21.3,P<0.05).结论 三种结直肠高度恶性腺癌(印戒细胞癌、黏液腺癌与低分化腺癌)是临床病理特点和预后不同的结直肠恶性肿瘤,印戒细胞癌的恶性度最高,预后差.

Colorectal high grade malignancy adenorarcinoma

Objective To explore clinieopathologieal features and prognosis in a high grade malignancy group of colorectal mueinous carcinoma, signet-ring cell carcinoma and low-differentiated carcinoma. Methods Retrospective analysis and follow-up were made on 148 patients with colorectal mucinous carcinoma, 55 patients with signet-ring cell carcinoma and 281 low- differentiated carcinoma treated in our hospital from 1988 to 2006. Obtained data were analyzed by SPSS13.0. Related factors underwent x2 analysis, survival analysis were estimated using Kaplan-Meier method and compared using the Log-rank test. Results Coloreetal signet-ring cell carcinoma were significantly different from mucinous carcinoma and low- differentiated carcinoma in gender, age, tumor location, bowel obstruction, operative modus, tumor embolism, tumor infiltration and lymph node metastasis(x2 = 7, 67,38.4,86.0,14.5,93.7,17.3,62. 1,24. 4,56.17 ,P <0.05). Median survival time was 24 months in signet-ring cell carcinoma, 47 months in mueinous carcinoma and 49 months in low- differentiated carcinoma. The difference is of significance(x2 = 21.3, P < 0.05). Conclusions Clinicopathological characteristics and prognosis of colorectal signet-ring cell carcinoma, mueinous carcinoma and low- differentiated carcinoma is of significant difference(P < 0.05). Malignancy of signet-ring cell carcinoma is higher with worse prognosis.