富血小板血浆修复慢性难愈合伤口的应用

【摘要】 目的 探讨富血小板血浆(PRP)修复慢性难愈合伤口的疗效。方法 分析从2010年10月至2012年3月,32例接受来源于自体的富含血小板血浆进行治疗的难愈合伤口患者。抽取患者静脉血30 mL,离心,与氯化钙和凝血酶混合后制成PRP凝胶敷于创面,凡士林纱布填塞,医用薄膜封闭创面,每7天更换1次,3次治疗为一疗程。评估治疗后伤口变化情况以及首次彻底清创后创面(治疗前V1)和2个月(治疗后V2)随访时创面体积。结果 32例患者使用3次PRP凝胶后,患者伤口均明显缩小,组织色泽红润血供良好,无明显渗液和脓液。治疗前测量创面体积(V1)为9.5±4.7 mL,治疗后2月时创面体积(V2)为1.7±0.9 mL,差异有统计学意义(P<0.05);治愈率31.2%,显效率93.8%。结论 富血小板血浆修复慢性难愈合伤口是一种有效、实用的治疗方法。

Effect of platelet-rich plasma on the treatment of hard agglut wounds

Objective To investigate the effect of platelet -rich plasma （PRP） on treatment for hard agglut wounds. Methods From October 2010 to March 2012, 32 patients with chronic wounds were received the treatment with PRP gelatin gel. The PRP preparation derived from 30 mL of venous blood was placed on the wound ,and then the wound was covered with Vaseline gauze and sealed up with a kind of medical membrane for 7 days before next dressing change. Three times was one course. The wound healing was evaluated by observation of wound surface and measurement of wound area before and two months after treatment. Results The wounds had an obvious improvement with fresh tissue after one treatment course , without further exudate. The wound volume changed from 9.5±4.7 mL （V1, before the treatment） to 1.7±0.9 mL （V2, after two months of treatment） （P0.05）. Among 32 patients, the cure rate was 31.2% and the effective rate was 93.8% . Conclusion Platelet-rich plasma is an effective and practical method in treatment of the chronic wounds.