淋巴管生成因子在肿瘤淋巴管生成中的研究进展

淋巴结转移是肿瘤分期的重要内容和预后指标,而淋巴管生成对肿瘤淋巴结转移等具有十分重要的作用.随着多种淋巴管内皮标记物的发现和淋巴管生成模型的建立,使得人们逐渐认识到淋巴管生成因子的表达和分子调控,以及其受体在促进肿瘤淋巴管生成过程中的地位.淋巴管生成因子正逐渐成为肿瘤淋巴道转移机制和抗肿瘤研究的新热点.

Lymphangiogenic factors in tumor lymphangiogenesis

Nodus lymphatic metabasis is an important index for tumor stage and a prognosis, while lymphatic vessel formation plays an important role in pathologic state. Many scholars demonstrated gradually the position of the lymphatic vessel factom and their receptors in the tumor metastases because of the findings of lymph vessel e-ndothelial tissue markers and the establishment of model for lymph vessel formation. Lymphangiogenic factors are gradually becomeing the focus in the studies of tumor lymp-hatic metastasis and cancer treatment of cancer.