Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis |
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| Authors: | Michael J Nowicki Thomas R Welch Nafees Ahmad I Kenneth Kuramoto Eleanor C Mendoza Jerome B Zeldis Bahige M Baroudy William F Balistreri |
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| Affiliation: | (1) Division of Pediatric Gastroenterology and Nutrition, Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio, USA;(2) Division of Pediatric Nephrology, Children's Hospital Research Foundation, Cincinnati, Ohio, USA;(3) Division of Molecular Virology, James N. Gamble Institute of Medical Research, Cincinnati, Ohio, USA;(4) Center for Blood Research, Sacramento Medical Foundation, Sacramento, California, USA;(5) Department of Internal Medicine, University of California, Davis, Sacramento, California, USA |
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| Abstract: | The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States. |
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| Keywords: | Hepatitis B virus Hepatitis C virus Idiopathic membranoproliferative glomerulonephritis |
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