| 兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用 |
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| 引用本文： | 施伟斌,江翰,王雪峰,王子豪,丁晶,刘颖斌.兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用[J].肝胆外科杂志,2011,19(3):226-228. |
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| 作者姓名： | 施伟斌 江翰 王雪峰 王子豪 丁晶 刘颖斌 |
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| 作者单位： | 上海交通大学医学院附属新华医院普外科,上海,200092 |
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| 基金项目： | 上海市科委纳米专项项目，上海市教委科研与创新计划 |
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| 摘 要： | 目的 通过建立一个原发性或转移性兔肝癌模型并应用纳米微泡造影剂对肿瘤进行早期监测,探讨纳米材料在肝癌超声诊断中的应用.方法 通过肿瘤组织块接种法制备兔肝癌模型并利用门静脉插管注射微泡造影剂对比增强显影.结果 模型建立后检测原位成瘤率为83.3％,采用5 MHz的发射频率,肝内主要血管及瘤块1分钟内显影得到增强.结论 靶...
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| 关 键 词： | VX2肿瘤 动物模型 肝癌 诊断 超声 |
THE ESTABLISHMENT OF RABBIT VX2 HEPATIC TUMOR MODEL AND THE APPLICATION OF NANO-SCALE MICROBUBBLE CONTRAST AGENT IN THE DIAGNOSIS OF THIS MODEL |
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| Affiliation: | (SHI Wei-bing,JIANG Han,WANG Xue-feng,et al.Department of general surgery,Shanghai Xinhua Hospital,Shanghai Jiaotong University,Shanghai 200092,China) |
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| Abstract: | Objective To investigate the the application of nano-scale microbubble contrast agent in hepatocarcinoma diagnosis by buliding a primary or metastatic liver carcinoma animal models.Methods Established the rabbit hepatocarcinoma model though vaccining tumor tissue in liver.Tumor can be develop by inject nano-scale microbubble contrast agent from portal vein.Result The mission success rate of model establishment is high to 83.3%,The imaging of major vascular and tumor in liver is enhanced,when using the 5MHz frequency mode.Conclusion Targeted nano ultrasound contrast agents are specific and sensitivity,nanoscale for ultrasound microbubble contrast enhancement is completely feasible. |
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| Keywords: | VX2 tumor animal model hepatocarcinoma diagnosis ultrasound |
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